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Localization of the gene for branchiootorenal syndrome to chromosome 8q
Journal article   Peer reviewed

Localization of the gene for branchiootorenal syndrome to chromosome 8q

Richard J.H Smith, Kevin B Coppage, Jennifer K.B Ankerstjerne, Dwayne T Capper, Shrawan Kumar, Judy Kenyon, Sue Tinley, Kimberly Comeau and William J Kimberling
Genomics (San Diego, Calif.), Vol.14(4), pp.841-844
1992
DOI: 10.1016/S0888-7543(05)80102-8
PMID: 1478663

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Abstract

Branchiootorenal syndrome is an autosomal dominant disorder that affects an estimated 2% of profoundly deaf children. In addition to hearing impairment, it is characterized by a lop-ear deformity, preauricular pits, branchial cleft sinus tracts, and renal anomalies. The pathogenesis of the disease remains unknown; however, the defective gene has been localized to chromosome 8q by family linkage studies.

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