Localization of virus and antibody response in mice infected persistently with MHV-JHM

G Jacobsen; S Perlman

doi:10.1007/978-1-4684-5823-7_79

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Localization of virus and antibody response in mice infected persistently with MHV-JHM

Journal article

Open access

Peer reviewed

Localization of virus and antibody response in mice infected persistently with MHV-JHM

G Jacobsen and S Perlman

Advances in experimental medicine and biology, Vol.276, pp.573-578

1990

DOI: 10.1007/978-1-4684-5823-7_79

PMID: 1966451

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Abstract

Suckling mice infected intranasally with MHV-JHM and nursed by immunized dams develop a late onset demyelinating encephalomyelitis. Analysis by in situ hybridization revealed that MHV-JHM entered the central nervous system (CNS) via the olfactory and trigeminal nerves and spread over the next two weeks to the spinal cord, prior to amplification at this site. Serial measurements of neutralizing antibody titers showed that the late onset disease developed in some mice at levels of antibody which protected mice from the fatal, acute encephalitis, supporting the notion that cell-mediated and not humoral immunity is important in protecting mice from MHV-JHM persistence.

Demyelinating Diseases - microbiology

Hepatitis, Viral, Animal - immunology

Hepatitis, Viral, Animal - pathology

Antisense Elements (Genetics)

Enzyme-Linked Immunosorbent Assay

Mice, Inbred C57BL

Neutralization Tests

Murine hepatitis virus - isolation & purification

RNA Probes

Animals

Antibodies, Viral - analysis

Demyelinating Diseases - immunology

Encephalomyelitis - immunology

Antibody Formation

Encephalomyelitis - microbiology

Mice

Demyelinating Diseases - pathology

Encephalomyelitis - pathology

Murine hepatitis virus - genetics

Details

Title: Subtitle: Localization of virus and antibody response in mice infected persistently with MHV-JHM
Creators: G Jacobsen - University of Iowa School of Medicine, Department of Pediatrics and Microbiology, University of Iowa Hospitals and Clinics, Iowa City 52242
S Perlman
Resource Type: Journal article
Publication Details: Advances in experimental medicine and biology, Vol.276, pp.573-578
DOI: 10.1007/978-1-4684-5823-7_79
PMID: 1966451
NLM abbreviation: Adv Exp Med Biol
ISSN: 0065-2598
Publisher: United States
Grant note: NS24401 / NINDS NIH HHS
Language: English
Date published: 1990
Academic Unit: Preventive and Community Dentistry; Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777349502771

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