Journal article
Locally Targeted Delivery of a Micron-Size Radiation Therapy Source Using Temperature-Sensitive Hydrogel
International journal of radiation oncology, biology, physics, Vol.88(5), pp.1142-1147
04/01/2014
DOI: 10.1016/j.ijrobp.2013.12.025
PMCID: PMC4264617
PMID: 24495593
Abstract
To propose a novel radiation therapy (RT) delivery modality: locally targeted delivery of micron-size RT sources by using temperature-sensitive hydrogel (RT-GEL) as an injectable vehicle.
Hydrogel is a water-like liquid at room temperature but gels at body temperature. Two US Food and Drug Administration-approved polymers were synthesized. Indium-111 (In-111) was used as the radioactive RT-GEL source. The release characteristics of In-111 from polymerized RT-GEL were evaluated. The injectability and efficacy of RT-GEL delivery to human breast tumor were tested using animal models with control datasets of RT-saline injection. As proof-of-concept studies, a total of 6 nude mice were tested by injecting 4 million tumor cells into their upper backs after a week of acclimatization. Three mice were injected with RT-GEL and 3 with RT-saline. Single-photon emission computed tomography (SPECT) and CT scans were performed on each mouse at 0, 24, and 48 h after injection. The efficacy of RT-GEL was determined by comparison with that of the control datasets by measuring kidney In-111 accumulation (mean nCi/cc), representing the distant diffusion of In-111.
RT-GEL was successfully injected into the tumor by using a 30-gauge needle. No difficulties due to polymerization of hydrogel during injection and intratumoral pressure were observed during RT-GEL injection. No back flow occurred for either RT-GEL or RT-saline. The residual tumor activities of In-111 were 49% at 24 h (44% at 48 h, respectively) for RT-GEL and 29% (22%, respectively) for RT-saline. Fused SPECT-CT images of RT-saline showed considerable kidney accumulation of In-111 (2886%, 261%, and 262% of RT-GEL at 0, 24, and 48 h, respectively).
RT-GEL was successfully injected and showed much higher residual tumor activity: 170% (200%, respectively), than that of RT-saline at 24 h (48 h, respectively) after injection with a minimal accumulation of In-111 to the kidneys. Preliminary data of RT-GEL as a delivery modality of a radiation source to a local tumor are promising.
Details
- Title: Subtitle
- Locally Targeted Delivery of a Micron-Size Radiation Therapy Source Using Temperature-Sensitive Hydrogel
- Creators
- Yusung Kim - Department of Radiation Oncology, The University of Iowa, Iowa City, IowaDong Rim Seol - Department of Orthopaedic Surgery, The University of Iowa, Iowa City, IowaSucheta Mohapatra - Department of Biomedical Engineering, The University of Iowa, Iowa City, IowaJohn J Sunderland - Department of Radiology, The University of Iowa, Iowa City, IowaMichael K Schultz - Department of Radiation Oncology, The University of Iowa, Iowa City, IowaFrederick E Domann - Department of Radiation Oncology, The University of Iowa, Iowa City, IowaTae-Hong Lim - Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.88(5), pp.1142-1147
- DOI
- 10.1016/j.ijrobp.2013.12.025
- PMID
- 24495593
- PMCID
- PMC4264617
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 04/01/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Orthodontics; Stead Family Department of Pediatrics; Pathology; Orthopedics and Rehabilitation; Surgery; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984047612102771
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