Journal article
Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
Hypertension (Dallas, Tex. 1979), Vol.78(6), pp.1750-1759
12/01/2021
DOI: 10.1161/HYPERTENSIONAHA.121.17875
PMCID: PMC8585708
PMID: 34719934
Abstract
While there is emerging evidence of peripheral microvascular dysfunction in patients with heart failure with preserved ejection fraction (HFpEF) that may be related to systemic inflammation and redox imbalance, disease-related changes in locomotor muscle microvascular responsiveness have not been determined. This study combined passive leg movement and biomarker assessments of inflammation and oxidative damage to determine the magnitude and mechanisms of lower limb microvascular function in patients with HFpEF (71±1 years; n=44) compared with healthy, similarly aged controls (68±2 years; n=39). Leg blood flow, heart rate, mean arterial pressure, and stroke volume were assessed, and plasma biomarkers of inflammation and oxidative damage were also determined. A significantly attenuated passive leg movement–induced peak change in leg blood flow (263±25 versus 371±31 mL/min, HFpEF versus control) and leg vascular conductance (2.99±0.32 versus 3.88±0.34 mL/min per mm Hg, HFpEF versus control) was observed in patients compared with controls. Similarly, the total hyperemic response to passive leg movement, expressed as leg blood flowAUC and leg vascular conductanceAUC, was ≈40% less in patients with HFpEF versus control. Significantly greater C-reactive protein, IL-6 (interleukin-6), and malondialdehyde were observed in patients with HFpEF but were not correlated with passive leg movement responses. These data provide new evidence of a decline in lower limb microvascular function within a milieu of vascular inflammation that may contribute to locomotor muscle dysfunction in patients with HFpEF.
Details
- Title: Subtitle
- Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
- Creators
- Michael A Francisco - University of UtahJoshua F Lee - University of UtahZachary Barrett-O'Keefe - Geriatric Research Education and Clinical CenterH Jonathan Groot - University of UtahStephen M Ratchford - Appalachian State UniversityKanokwan Bunsawat - University of UtahJeremy K Alpenglow - Geriatric Research Education and Clinical CenterJohn J Ryan - University of UtahJose N Nativi - University of UtahRussell S Richardson - University of UtahD Walter Wray - University of Utah
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.78(6), pp.1750-1759
- DOI
- 10.1161/HYPERTENSIONAHA.121.17875
- PMID
- 34719934
- PMCID
- PMC8585708
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Grant note
- I21 RX001433 / RRD VA I01 RX001311 / RRD VA I01 CX002152 / CSRD VA T32 HL139451 / NHLBI NIH HHS R01 HL118313 / NHLBI NIH HHS R56 AG057584 / NIA NIH HHS I01 RX001697 / RRD VA
- Language
- English
- Date published
- 12/01/2021
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984948044102771
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