Long Circulating Reduced Graphene Oxide-Iron Oxide Nanoparticles for Efficient Tumor Targeting and Multimodality Imaging

Cheng Xu; Sixiang Shi; Liangzhu Feng; Feng Chen; Stephen A. Graves; Emily B. Ehlerding; Shreya Goel; Haiyan Sun; Christopher G. England; Robert J. Nickles; Zhuang Liu; Taihong Wang; Weibo Cai

doi:10.1039/c5nr09193d

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Long Circulating Reduced Graphene Oxide-Iron Oxide Nanoparticles for Efficient Tumor Targeting and Multimodality Imaging

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Long Circulating Reduced Graphene Oxide-Iron Oxide Nanoparticles for Efficient Tumor Targeting and Multimodality Imaging

Cheng Xu, Sixiang Shi, Liangzhu Feng, Feng Chen, Stephen A. Graves, Emily B. Ehlerding, Shreya Goel, Haiyan Sun, Christopher G. England, Robert J. Nickles, …

Nanoscale, Vol.8(25), pp.12683-12692

07/07/2016

DOI: 10.1039/c5nr09193d

PMCID: PMC4919229

PMID: 27109431

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https://www.ncbi.nlm.nih.gov/pmc/articles/4919229View

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Abstract

Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve the solubility of inorganic nanoparticles, prevent their aggregation and prolong their in vivo blood circulation half-life. Herein, we developed double-PEGylated biocompatible reduced graphene oxide nanosheets anchored with iron oxide nanoparticles (RGO-IONP- 1st PEG- 2nd PEG). The nanoconjugates exhibited prolonged blood circulation half-life (~27.7 h) and remarkable tumor accumulation (>11 %ID/g) via enhanced permeability and retention (EPR) effect. Due to strong near-infrared absorbance and superparamagnetism of RGO-IONP- 1st PEG- 2nd PEG, multimodality imaging combining positron emission tomography imaging (PET) with magnetic resonance imaging (MRI) and photoacoustic (PA) imaging was successfully achieved. The promising results suggest great potential of these nanoconjugates for multi-dimensional and more accurate tumor diagnosis and therapy in the future. Double PEGylated reduced graphene oxide nanosheets anchored with iron oxide nanoparticles exhibited ultra-long blood circulation half-life and remarkably high tumor accumulation, which could be utilized as a multimodality imaging nanoprobe for combined PET, MRI and photoacoustic imaging.

Iron oxide nanoparticles

Magnetic resonance imaging

PEGylation

Photoacoustic imaging

Positron emission tomography

Reduced graphene oxide

Details

Title: Subtitle: Long Circulating Reduced Graphene Oxide-Iron Oxide Nanoparticles for Efficient Tumor Targeting and Multimodality Imaging
Creators: Cheng Xu - University of Wisconsin–Madison
Sixiang Shi - University of Wisconsin–Madison
Liangzhu Feng - Soochow University
Feng Chen - University of Wisconsin–Madison
Stephen A. Graves - University of Wisconsin–Madison
Emily B. Ehlerding - University of Wisconsin–Madison
Shreya Goel - University of Wisconsin–Madison
Haiyan Sun - University of Wisconsin–Madison
Christopher G. England - University of Wisconsin–Madison
Robert J. Nickles - University of Wisconsin–Madison
Zhuang Liu - Soochow University
Taihong Wang - Hunan University
Weibo Cai - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Nanoscale, Vol.8(25), pp.12683-12692
DOI: 10.1039/c5nr09193d
PMID: 27109431
PMCID: PMC4919229
NLM abbreviation: Nanoscale
ISSN: 2040-3364
eISSN: 2040-3372
Grant note: DOI: 10.13039/501100004543, name: China Scholarship Council; DOI: 10.13039/100000009, name: Foundation for the National Institutes of Health, award: 1R01CA169365, P30CA014520, T32CA009206, T32GM008505; DOI: 10.13039/100000048, name: American Cancer Society, award: 125246-RSG-13-099-01-CCE; DOI: 10.13039/100008074, name: Grainger Foundation, award: Wisconsin Distinguished Graduate Fellowship
Language: English
Date published: 07/07/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
Record Identifier: 9984383903602771

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