Long-Term Burden of Increased Body Mass Index from Childhood on Adult Dyslipidemia: The i3C Consortium Study

Yinkun Yan; Lydia A Bazzano; Markus Juonala; Olli T Raitakari; Jorma S A Viikari; Ronald Prineas; Terence Dwyer; Alan Sinaiko; Trudy L Burns; Stephen R Daniels; Jessica G Woo; Philip R Khoury; Elaine M Urbina; David R Jacobs Jr; Tian Hu; Julia Steinberger; Alison Venn; Wei Chen

doi:10.3390/jcm8101725

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Long-Term Burden of Increased Body Mass Index from Childhood on Adult Dyslipidemia: The i3C Consortium Study

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Long-Term Burden of Increased Body Mass Index from Childhood on Adult Dyslipidemia: The i3C Consortium Study

Yinkun Yan, Lydia A Bazzano, Markus Juonala, Olli T Raitakari, Jorma S A Viikari, Ronald Prineas, Terence Dwyer, Alan Sinaiko, Trudy L Burns, Stephen R Daniels, …

Journal of clinical medicine, Vol.8(10), 1725

10/18/2019

DOI: 10.3390/jcm8101725

PMCID: PMC6832308

PMID: 31635325

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Abstract

Data are limited regarding the association of cumulative burden and trajectory of body mass index (BMI) from early life with adult lipid disorders. The study cohort consisted of 5195 adults who had BMI repeatedly measured 4 to 21 times from childhood and had blood lipid measurements of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) and information on lipid-lowering medications in the last adult survey. The area under the curve (AUC) was calculated as a measure of long-term burden (total AUC) and trends (incremental AUC) of BMI. Participants with dyslipidemia, high LDL-C, low HDL-C and high TG had consistently and significantly higher BMI levels from childhood to adulthood compared to those with normal lipid levels. After adjusting for age, race, sex, and cohort, increased risk of adult dyslipidemia was significantly associated with higher values of childhood BMI, adulthood BMI, total AUC and incremental AUC, with odds ratio (95% confidence interval) = 1.22 (1.15-1.29), 1.85 (1.74-1.97), 1.61 (1.52-1.71), and 1.59 (1.50-1.69), respectively, and < 0.001 for all. The association patterns were similar in most race-sex subgroups. Adults with dyslipidemia versus normal lipid levels have consistently higher levels and distinct life-course trajectories of BMI, suggesting that the impact of excessive body weight on dyslipidemia originates in early life.

longitudinal study

childhood

dyslipidemia

body mass index

Details

Title: Subtitle: Long-Term Burden of Increased Body Mass Index from Childhood on Adult Dyslipidemia: The i3C Consortium Study
Creators: Yinkun Yan - Tulane University
Lydia A Bazzano - Tulane University
Markus Juonala - Turku University Hospital
Olli T Raitakari - University of Turku
Jorma S A Viikari - Turku University Hospital
Ronald Prineas - Wake Forest University
Terence Dwyer - The George Institute for Global Health
Alan Sinaiko - University of Minnesota
Trudy L Burns - University of Iowa
Stephen R Daniels - University of Colorado Denver
Jessica G Woo - Cincinnati Children's Hospital Medical Center
Philip R Khoury - University of Cincinnati Medical Center
Elaine M Urbina - Cincinnati Children's Hospital Medical Center
David R Jacobs Jr - University of Minnesota
Tian Hu - University of Minnesota
Julia Steinberger - University of Minnesota
Alison Venn - University of Tasmania
Wei Chen - Tulane University
Resource Type: Journal article
Publication Details: Journal of clinical medicine, Vol.8(10), 1725
DOI: 10.3390/jcm8101725
PMID: 31635325
PMCID: PMC6832308
NLM abbreviation: J Clin Med
ISSN: 2077-0383
eISSN: 2077-0383
Grant note: R01HL121230 / NHLBI NIH HHS R01 HL121230 / NHLBI NIH HHS 286284, 134309, 126925, 121584, 124282, 129378, 117787, and 41071 / Academy of Finland U54 GM104940 / NIGMS NIH HHS R01AG016592 / NIA NIH HHS R03AG060619 / NIA NIH HHS
Language: English
Date published: 10/18/2019
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984363630902771

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