Journal article
Long-Term Follow-Up of Brachytherapy in Untreated Malignant Glioma
Journal of radiosurgery, Vol.2(3), pp.129-133
09/1999
DOI: 10.1023/A:1022914612628
Abstract
Objective: Long-term follow-up of patients with malignant glioma randomized to treatment with and without brachytherapy. Methods: Twenty-six patients were randomized to brachytherapy and external radiation, and 23 to external radiation alone. There were 19 and 17 glioblastomas, and 3 and 8 anaplastic astrocytomas, in the nonimplant and implant groups, respectively, and 1 malignant oligodendroglioma in each group. For brachytherapy, iodine- 125 seeds were implanted to deliver a homogeneous dose of 40 cGy/hr for a maximum of 6000 cGy to the enhancing tumor margin. All patients received external radiation for a total of 6020 cGy delivered to the tumor plus 3 cm margin over 7 weeks, followed by BCNU chemotherapy. Conclusions: The median survival was 78 and 66 weeks in the implant and nonimplant groups respectively, and their survival curves were not different (log rank, p=0.394). A significant multivariate relationship did exist between survival and age (p=0.0092), tumor grade (p=0.0001), and Karnofsky (p=0.021). Treatment with brachytherapy is subject to selection bias, which does exclude a large proportion of patients.
Details
- Title: Subtitle
- Long-Term Follow-Up of Brachytherapy in Untreated Malignant Glioma
- Creators
- P Hitchon - Division of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IowaPamela Schneider - Division of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IowaJ VanGilder - Division of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IowaJ Torner - Department of Biostatistics University of Iowa Hospitals and Clinics Iowa City IowaB Wen - Section of Radiation Oncology University of Iowa Hospitals and Clinics Iowa City IowaS Jani - Section of Radiation Oncology University of Iowa Hospitals and Clinics Iowa City Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of radiosurgery, Vol.2(3), pp.129-133
- DOI
- 10.1023/A:1022914612628
- ISSN
- 1096-4053
- eISSN
- 1573-8752
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- Language
- English
- Date published
- 09/1999
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984040462302771
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