Long-Term Food Restriction, Deprenyl, and Nimodipine Treatment on Life Expectancy and Blood Pressure of Stroke-Prone Rats

H Stevens; S Knollema; G De Jong; J Korf; P.G.M Luiten

doi:10.1016/S0197-4580(98)00059-1

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Long-Term Food Restriction, Deprenyl, and Nimodipine Treatment on Life Expectancy and Blood Pressure of Stroke-Prone Rats

Journal article

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Peer reviewed

Long-Term Food Restriction, Deprenyl, and Nimodipine Treatment on Life Expectancy and Blood Pressure of Stroke-Prone Rats

H Stevens, S Knollema, G De Jong, J Korf and P.G.M Luiten

Neurobiology of aging, Vol.19(3), pp.273-276

1998

DOI: 10.1016/S0197-4580(98)00059-1

PMID: 9662003

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Abstract

We determined whether food restriction or the drugs nimodipine (Ca 2+ antagonist) and deprenyl (a MAO-B inhibitor) prevent the development of stroke in the spontaneously hypertensive stroke-prone rat (SHR-SP). Forty male SHR-SP rats, in the age of 34 weeks, were exposed to various treatments. During a period of 27 weeks, survival and blood pressure were followed. In the control and deprenyl group, the blood pressure values remained unchanged; 50% had died after 27 weeks. All rats that were treated with nimodipine survived. After food restriction, 7/8 rats survived and showed a lower blood pressure. This study in SHR-PR rats shows the superiority of nimodipine on survival, and the potential of food restriction as a stroke-preventing measure.

Hypertension

Stroke prevention

Nimodipine

Deprenyl

Stroke-prone rats

Blood pressure

Food restriction

Details

Title: Subtitle: Long-Term Food Restriction, Deprenyl, and Nimodipine Treatment on Life Expectancy and Blood Pressure of Stroke-Prone Rats
Creators: H Stevens - Department of Biological Psychiatry, University Hospital Groningen, Groningen, Netherlands
S Knollema - Department of Biological Psychiatry, University Hospital Groningen, Groningen, Netherlands
G De Jong - Department of Animal Physiology University of Groningen, Groningen, Netherlands
J Korf - Department of Biological Psychiatry, University Hospital Groningen, Groningen, Netherlands
P.G.M Luiten - Department of Biological Psychiatry, University Hospital Groningen, Groningen, Netherlands
Resource Type: Journal article
Publication Details: Neurobiology of aging, Vol.19(3), pp.273-276
Publisher: Elsevier Inc
DOI: 10.1016/S0197-4580(98)00059-1
PMID: 9662003
ISSN: 0197-4580
eISSN: 1558-1497
Language: English
Date published: 1998
Academic Unit: Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984072068702771

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