Journal article
Long-Term Health-Related Quality of Life of Autologous Hematopoietic Cell Transplantation Patients and Nontransplant Patients With Aggressive Lymphoma: A Prospective Cohort Analysis
JCO oncology practice, Vol.18(7), pp.e1069-e1080
07/2022
DOI: 10.1200/OP.21.00694
PMCID: PMC9287288
PMID: 35594505
Abstract
This study assessed the long-term quality of life (QOL) of patients with aggressive lymphoma subtypes treated with autologous hematopoietic cell transplant (autoHCT) compared with those without history of transplant.
Patient-reported QOL measures were prospectively gathered from patients enrolled in the Iowa/Mayo Specialized Program of Research Excellence Molecular Epidemiology Resource cohort with aggressive lymphoma subtypes. QOL was measured using the Functional Assessment of Cancer Therapy-General (FACT-G), Functional Assessment of Chronic Illness Therapy-Fatigue Scale, State-Trait Anxiety Inventory (STAI), and Profile of Mood States instruments and with a numeric rating scale for overall QOL and spiritual QOL. The autoHCT group and no HCT groups were compared at 3 years (FU3) and 6 years (FU6) after lymphoma diagnosis.
In total, 980 patients with lymphoma (106 autoHCT and 874 no HCT) diagnosed between 2002 and 2013 were included for analysis. The mean FACT-G total score was similar in the autoHCT and no HCT groups at FU3 (89.9
90.1,
= .64) and also at FU6 (91.5
89.6,
= .44). No differences between the autoHCT and no HCT groups were identified in the FACT subscales. The STAI identified lower anxiety in the autoHCT group by mean STAI1 (state) at FU3 (30.1
33.4,
< .01) and by mean STAI2 (trait) at FU6 (30.1
33.5,
= .02). No other clinically meaningful differences were identified between the two groups using the other QOL instruments.
Patients remaining in remission at 3 and 6 years after diagnosis had a high level of QOL with no significant differences associated with history of treatment with autoHCT.
Details
- Title: Subtitle
- Long-Term Health-Related Quality of Life of Autologous Hematopoietic Cell Transplantation Patients and Nontransplant Patients With Aggressive Lymphoma: A Prospective Cohort Analysis
- Creators
- Christopher S Strouse - University of IowaMelissa C Larson - Mayo ClinicShawna L Ehlers - Mayo ClinicKathleen J Yost - Mayo ClinicMatthew J Maurer - Department of Health Sciences Research, Mayo Clinic, Rochester, MNStephen M Ansell - Mayo ClinicDavid J Inwards - Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MNPatrick B Johnston - Mayo ClinicIvana N Micallef - Mayo ClinicBrian K Link - University of IowaUmar Farooq - University of IowaJames R Cerhan - Mayo ClinicCarrie A Thompson - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- JCO oncology practice, Vol.18(7), pp.e1069-e1080
- DOI
- 10.1200/OP.21.00694
- PMID
- 35594505
- PMCID
- PMC9287288
- ISSN
- 2688-1527
- eISSN
- 2688-1535
- Grant note
- P30 CA015083 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
- Language
- English
- Date published
- 07/2022
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984359831902771
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