Journal article
Long-Term Neuropsychological, Neuroanatomical, and Life Outcome in Hippocampal Amnesia
Clinical neuropsychologist, Vol.26(2), pp.335-369
02/01/2012
DOI: 10.1080/13854046.2012.655781
PMCID: PMC3390923
PMID: 22401298
Abstract
Focal bilateral hippocampal damage typically causes severe and selective amnesia for new declarative information (facts and events), a cognitive deficit that greatly impacts the ability to live a normal, fully independent life. We describe the case of 1846, a 48-year-old woman with profound hippocampal amnesia following status epilepticus and an associated anoxic episode at age 30. Patient 1846 has undergone extensive neuropsychological testing on many occasions over the 18 years since her injury, and we present data indicating that her memory impairment has remained severe and stable during that time. New, high-resolution, structural MRI studies of 1846's brain reveal substantial bilateral hippocampal atrophy resembling that of other well-known amnesic patients. In spite of severe amnesia 1846 lives a full and mostly independent adult life, facilitated by an extensive social support network of family and friends. Her case provides an example of a rare and unlikely positive outcome in the face of severe memory problems.
Details
- Title: Subtitle
- Long-Term Neuropsychological, Neuroanatomical, and Life Outcome in Hippocampal Amnesia
- Creators
- David E Warren - Department of Neurology , University of Iowa College of MedicineMelissa C Duff - Department of Communication Sciences and Disorders , University of IowaVincent Magnotta - Department of Radiology , University of Iowa College of MedicineAristides A Capizzano - Department of Radiology , University of Iowa College of MedicineMartin D Cassell - Department of Anatomy and Cell Biology , University of IowaDaniel Tranel - Department of Psychology , University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical neuropsychologist, Vol.26(2), pp.335-369
- DOI
- 10.1080/13854046.2012.655781
- PMID
- 22401298
- PMCID
- PMC3390923
- NLM abbreviation
- Clin Neuropsychol
- ISSN
- 1385-4046
- eISSN
- 1744-4144
- Publisher
- Psychology Press
- Language
- English
- Date published
- 02/01/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Anatomy and Cell Biology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002493402771
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