Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV)

Timothy M Boyce; S. Scott Whitmore; Katayoun Varzavand; Stephen R Russell; Elliott H Sohn; James C Folk; Edwin M Stone; Ian C Han

doi:10.1016/j.ajo.2021.07.015

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Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV)

Journal article

Peer reviewed

Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV)

Timothy M Boyce, S. Scott Whitmore, Katayoun Varzavand, Stephen R Russell, Elliott H Sohn, James C Folk, Edwin M Stone and Ian C Han

American journal of ophthalmology, Vol.233, pp.144-152

01/2022

DOI: 10.1016/j.ajo.2021.07.015

PMCID: PMC9177238

PMID: 34302771

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https://www.ncbi.nlm.nih.gov/pmc/articles/9177238View

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Abstract

Purpose Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a rare disorder characterized by uveitis, retinal neovascularization, and retinal degeneration. We sought to describe the course of treated and untreated ADNIV and to identify risk factors for severe vision loss. Design Observational case series. Methods Clinical data from ADNIV patients from 4 families seen from 1967 through 2019 at a single academic, tertiary referral center were reviewed. The main outcome measures were visual acuity at baseline and follow-up, as well as risk factors for vision loss. Results A total of 130 eyes from 65 ADNIV patients (45 female, 20 male; mean age 40.8 years, range 6-77 years) were included. Mean best corrected visual acuity (BCVA) at presentation was LogMAR 0.59 (about Snellen 20/80). Longitudinal analysis included 84 eyes from 42 patients (31 female, 11 male), with mean follow-up of 17.3 years (range 2-43.6 years). Mean BCVA at last follow-up was LogMAR 1.48 (about Snellen 20/600). The disease accelerated in the fifth decade of life, during which the majority of eyes went from normal vision or mild vision loss to at least moderate vision loss (20/70 Snellen equivalent); 25 eyes from 16 patients (29.8%;) showed a steep trajectory of vision loss to no light perception. Tractional retinal detachment was the greatest risk factor for severe vision loss (BCVA <20/200) on multivariable analysis (P < .05). Conclusions Patients with ADNIV have a high lifetime risk of severe vision loss. Tractional retinal detachment is an important risk factor for poor vision.

Details

Title: Subtitle: Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV)
Creators: Timothy M Boyce - Roy J. and Lucille A. Carver College of Medicine
S. Scott Whitmore
Katayoun Varzavand - Roy J. and Lucille A. Carver College of Medicine
Stephen R Russell - Roy J. and Lucille A. Carver College of Medicine
Elliott H Sohn - Roy J. and Lucille A. Carver College of Medicine
James C Folk - Roy J. and Lucille A. Carver College of Medicine
Edwin M Stone - Roy J. and Lucille A. Carver College of Medicine
Ian C Han - University of Iowa
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.233, pp.144-152
DOI: 10.1016/j.ajo.2021.07.015
PMID: 34302771
PMCID: PMC9177238
NLM abbreviation: Am J Ophthalmol
ISSN: 0002-9394
eISSN: 1879-1891
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000053, name: National Eye Institute, award: P30 EY025580, R01-EY026547; DOI: 10.13039/100008893, name: University of Iowa
Language: English
Electronic publication date: 07/2021
Date published: 01/2022
Academic Unit: The University of Iowa Institute for Vision Research; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9984186925402771

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