Journal article
Long-Term Outcomes of Recipients of Liver Transplants from Living Donors Treated with a Very Low-Calorie Diet
Journal of transplantation, Vol.2024, pp.9024204-6
05/02/2024
DOI: 10.1155/2024/9024204
PMCID: PMC11081753
PMID: 38725471
Abstract
The increasing prevalence of steatotic liver disease (SLD) in potential living donors is concerning, as it limits donor's availability amid rising demand. OPTIFAST very low-calorie diet (VLCD), a meal replacement product, effectively reduces weight and hepatic steatosis before transplantation. However, data on the outcomes of recipients of VLCD-treated donors are lacking. We conducted a single-center, retrospective study on 199 living donor liver transplant recipients at Toronto General Hospital, Canada, between January 2015 and January 2020. We compared the 1-year posttransplant outcomes between recipients who received organs from donors treated with VLCD (N = 34) for either weight loss or steatosis reduction, with those who did not require treatment (N = 165). Our analysis revealed no statistically significant differences in the rates of postoperative complications (23% vs 32.4%, p=0.3) or intensive care unit stays (70.9% vs 70.6%, p=1) between recipients of non-VLCD and VLCD grafts. Following adjusted multivariate logistic regression, receipt of VLCD grafts was not associated with increased hospital length of stay. In addition, one-year mortality did not differ between the two groups (4.2% non-VLCD recipients vs 2.9% VLCD recipients, p=0.6). OPTIFAST VLCD treatment for liver donors demonstrates positive and safe outcomes in recipients, expanding the pool of potential living donors for increased organ availability.
Details
- Title: Subtitle
- Long-Term Outcomes of Recipients of Liver Transplants from Living Donors Treated with a Very Low-Calorie Diet
- Creators
- Hannah Wozniak - University of TorontoSara Naimimohasses - University Health NetworkToru Goto - University Health NetworkGonzalo Sapisochin - University Health NetworkBlayne Sayed - University Health NetworkAnand Ghanekar - University Health NetworkMark Cattral - University Health NetworkNazia Selzner - University Health Network
- Resource Type
- Journal article
- Publication Details
- Journal of transplantation, Vol.2024, pp.9024204-6
- DOI
- 10.1155/2024/9024204
- PMID
- 38725471
- PMCID
- PMC11081753
- NLM abbreviation
- J Transplant
- ISSN
- 2090-0007
- eISSN
- 2090-0015
- Publisher
- Hindawi Publishing Group
- Number of pages
- 6
- Language
- English
- Date published
- 05/02/2024
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984772254602771
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