Long-Term Outcomes of Women With Peripartum Cardiomyopathy Having Subsequent Pregnancies

Pavida Pachariyanon; Hari Bogabathina; Keerthish Jaisingh; Morni Modi; Kalgi Modi

doi:10.1016/j.jacc.2023.04.043

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Long-Term Outcomes of Women With Peripartum Cardiomyopathy Having Subsequent Pregnancies

Journal article

Open access

Peer reviewed

Long-Term Outcomes of Women With Peripartum Cardiomyopathy Having Subsequent Pregnancies

Pavida Pachariyanon, Hari Bogabathina, Keerthish Jaisingh, Morni Modi and Kalgi Modi

Journal of the American College of Cardiology, Vol.82(1), pp.16-26

07/04/2023

DOI: 10.1016/j.jacc.2023.04.043

PMID: 37380299

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Abstract

Long-term maternal outcomes of subsequent pregnancies (SSPs) in patients with peripartum cardiomyopathy (PPCM) have not been analyzed. The goal of this study was to evaluate the long-term survival of SSPs in women with PPCM. We conducted a retrospective review of 137 PPCMs in the registry. The clinical and echocardiographic findings were compared between the recovery group (RG) and nonrecovery group (NRG), defined as left ventricular ejection fraction ≥50% and <50% after an index of pregnancy, respectively. Forty-five patients with SSPs were included with a mean age of 27.0 ± 6.1 years, 80% were of African American descent, and 75.6% from a low socioeconomic background. Thirty (66.7%) women were in the RG. Overall, SSPs were associated with a decrease in mean left ventricular ejection fraction from 45.1% ± 13.7% to 41.2% ± 14.5% (P = 0.009). At 5 years, adverse outcomes were significantly higher in the NRG compared with the RG (53.3% vs 20%; P = 0.04), driven by relapse PPCM (53.3% vs 20.0%; P = 0.03). Five-year all-cause mortality was 13.33% in the NRG compared with 3.33% in the RG (P = 0.25). At a median follow-up of 8 years, adverse outcomes and all-cause mortality rates were similar in the NRG and RG (53.3% vs 33.3% [P = 0.20] and 20% vs 20%, respectively). Subsequent pregnancies in women with PPCM are associated with adverse events. The normalization of left ventricular function does not guarantee a favorable outcome in the SSPs. [Display omitted]

future pregnancy

peripartum cardiomyopathy

recovery of left ventricular systolic function

recovery of LVEF

subsequent pregnancy

Details

Title: Subtitle: Long-Term Outcomes of Women With Peripartum Cardiomyopathy Having Subsequent Pregnancies
Creators: Pavida Pachariyanon - Louisiana State University
Hari Bogabathina - Louisiana State University
Keerthish Jaisingh - Louisiana State University
Morni Modi - School of Medicine, Louisiana State University Health, Shreveport, Louisiana, USA
Kalgi Modi - Louisiana State University
Resource Type: Journal article
Publication Details: Journal of the American College of Cardiology, Vol.82(1), pp.16-26
Publisher: Elsevier Inc
DOI: 10.1016/j.jacc.2023.04.043
PMID: 37380299
ISSN: 0735-1097
eISSN: 1558-3597
Language: English
Date published: 07/04/2023
Academic Unit: Internal Medicine
Record Identifier: 9984691513502771

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