Journal article
Long-Term Psychiatric Outcomes in Adults with History of Pediatric Traumatic Brain Injury
Journal of neurotrauma, Vol.38(11), pp.1515-1525
06/01/2021
DOI: 10.1089/neu.2020.7238
PMCID: PMC8336207
PMID: 33765846
Abstract
The objective of the study was to compare psychiatric outcomes in adults with and without history of pediatric traumatic brain injury (TBI). Youth ages 6 to 14 years hospitalized for TBI from 1992 to 1994 were assessed at baseline and at 3, 6, 12, and 24 months post-injury. In the current study, psychiatric assessments were repeated at 24 years post-injury with the same cohort, now adults ages 29 to 39 years. A control group of healthy adults also was recruited for one-time cross-sectional assessments. Outcome measures included: 1) presence of a psychiatric disorder since the 24-month assessment not present before the TBI ("novel psychiatric disorder," NPD), or in the control group, the presence of a psychiatric disorder that developed after the mean age of injury of the TBI group plus 2 years; and 2) Time-to-Event for onset of an NPD during the same time periods. In the TBI group, NPDs were significantly more common, and presence of a current NPD was significantly predicted by presence of a pre-injury lifetime psychiatric disorder and by abnormal day-of-injury computed tomography (CT) scan. Compared with controls, the TBI group also had significantly shorter Time-to-Event for onset of any NPD. These findings demonstrate that long-term psychiatric outcomes in adults previously hospitalized for pediatric TBI are significantly worse when compared with adult controls without history of pediatric TBI, both in terms of prevalence and earlier onset of NPD. Further, in the TBI group, long-term NPD outcome is predicted independently by presence of pre-injury psychiatric disorder and abnormal day-of-injury CT scan.
Details
- Title: Subtitle
- Long-Term Psychiatric Outcomes in Adults with History of Pediatric Traumatic Brain Injury
- Creators
- Hattan Arif - University of California, San DiegoEmily A Troyer - University of California, San DiegoJane S Paulsen - University of IowaFlorin Vaida - University of California, San DiegoElisabeth A Wilde - University of UtahErin D Bigler - Brigham Young UniversityJohn R Hesselink - University of California, San DiegoTony T Yang - University of California, San FranciscoOlga Tymofiyeva - University of California SystemOwen Wade - University of IowaJeffrey E Max - University of California, San Diego
- Resource Type
- Journal article
- Publication Details
- Journal of neurotrauma, Vol.38(11), pp.1515-1525
- DOI
- 10.1089/neu.2020.7238
- PMID
- 33765846
- PMCID
- PMC8336207
- ISSN
- 0897-7151
- eISSN
- 1557-9042
- Grant note
- R01 NS103475 / NINDS NIH HHS R21 AT009173 / NCCIH NIH HHS UL1 TR001872 / NCATS NIH HHS R01 NS105509 / NINDS NIH HHS U01 NS103475 / NINDS NIH HHS R61 AT009864 / NCCIH NIH HHS
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984383288902771
Metrics
4 Record Views