Long-Term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study

Catherine S Bradley; Robert Gallop; Siobhan Sutcliffe; Karl J Kreder; H Henry Lai; J Quentin Clemens; Bruce D Naliboff; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

doi:10.1016/j.urology.2022.07.045

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Long-Term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study

Journal article

Peer reviewed

Long-Term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study

Catherine S Bradley, Robert Gallop, Siobhan Sutcliffe, Karl J Kreder, H Henry Lai, J Quentin Clemens, Bruce D Naliboff and Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

Urology (Ridgewood, N.J.), Vol.169, pp.58-64

11/01/2022

DOI: 10.1016/j.urology.2022.07.045

PMCID: PMC10590538

PMID: 35961564

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10590538/pdf/nihms-1932456.pdfView

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Abstract

OBJECTIVETo characterize Urologic Chronic Pelvic Pain Syndrome (UCPPS) pain and urinary symptom trajectories with up to 9 years of follow-up and evaluate whether initial 1-year trajectories are associated with longer-term changes. MATERIALS AND METHODSData were analyzed from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Network's prospective observational protocols including the Epidemiology and Phenotyping Study (EPS; baseline to Year 1), EPS Extension (EXT; Years 1-5), and Symptom Patterns Study (SPS: 3-year study; Years 3-9). Adults with Interstitial Cystitis/Bladder Pain Syndrome or Chronic Prostatitis/Chronic Pelvic Pain Syndrome provided patient-reported assessments biweekly (EPS), every 4 months (EXT), or quarterly (SPS). Primary outcomes were composite pain (0-28) and urinary (0-25) severity scores. Multi-phase mixed effects models estimated outcomes over time, adjusted for baseline severity and stratified by EPS symptom trajectory. RESULTS163 participants (52% women; mean ± SD age 46.4 ± 16.1 years) completed EPS and enrolled in EXT; 67 also enrolled in SPS. Median follow-up was 4.6 years (range 1.3-9.0). After 1 year: 27.6%, 44.8% and 27.6% and 27.0%, 38.0% and 35.0% were improved, stable or worse in pain and urinary symptom severity, respectively. On average, pain and urinary symptom scores did not change further during EXT and SPS periods. CONCLUSIONSWomen and men with UCPPS showed remarkable stability in pain and urinary symptom severity for up to 9 years, irrespective of their initial symptom trajectory, suggesting UCPPS is a chronic condition with stable symptoms over multiple years of follow-up.

Details

Title: Subtitle: Long-Term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study
Creators: Catherine S Bradley - Roy J. and Lucille A. Carver College of Medicine
Robert Gallop
Siobhan Sutcliffe
Karl J Kreder
H Henry Lai
J Quentin Clemens
Bruce D Naliboff
Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
Resource Type: Journal article
Publication Details: Urology (Ridgewood, N.J.), Vol.169, pp.58-64
DOI: 10.1016/j.urology.2022.07.045
PMID: 35961564
PMCID: PMC10590538
NLM abbreviation: Urology
ISSN: 0090-4295
eISSN: 1527-9995
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: U01 DK082316, U01 DK082325, U01 DK082333, U01 DK082344, U01 DK082345, U01 DK082370, U01 DK103227, U01 DK103260, U01 DK103271, U01 K082342; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: U01 DK082315
Language: English
Date published: 11/01/2022
Academic Unit: Epidemiology; Obstetrics and Gynecology; Urology
Record Identifier: 9984315563302771

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