Long-acting preexposure prophylaxis in low- and middle-income countries: key considerations for implementation

Quanhathai Kaewpoowat; Suwat Chariyalertsak; Nittaya Phanuphak; Reshmie A Ramautarsing

doi:10.1097/COH.0000000000000729

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Journal article

Long-acting preexposure prophylaxis in low- and middle-income countries: key considerations for implementation

Quanhathai Kaewpoowat, Suwat Chariyalertsak, Nittaya Phanuphak and Reshmie A Ramautarsing

Current opinion in HIV & AIDS, Vol.17(3), pp.135-144

05/01/2022

DOI: 10.1097/COH.0000000000000729

PMID: 35439788

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Abstract

HIV preexposure prophylaxis (PrEP) is a key tool in ending the HIV epidemic. Long-acting cabotegravir (LA- CAB) phase II/III studies revealed promising efficacy in preventing HIV acquisition. Here, we discuss key considerations for implementing LA-CAB in low- and middle-income countries (LMIC). PrEP roll out in LMIC is still far from ideal, and contextual factors within LMIC vary widely. Implementation science studies are urgently needed to optimize the implementation of LA-CAB in different settings, consider effective service delivery models, and ensure program sustainability. Preferences and concerns regarding LA-CAB among potential users are unknown but likely specific to local context. Demedicalized and simplified PrEP service delivery increases uptake, and ways to safely and effectively do the same for LA- CAB need to be explored. Although ideally LA-CAB should be an additional choice of HIV prevention method, its cost will be the major determinant in deciding its position as a first line choice or restricted second-line option. LA-CAB has the potential to enhance PrEP uptake. However, several implementation challenges need to be explored and addressed to ensure it can be accessed and utilized in different settings by those who need it the most.

Acquired Immunodeficiency Syndrome - drug therapy

Anti-HIV Agents - therapeutic use

Developing Countries

HIV Infections - drug therapy

HIV Infections - prevention & control

Humans

Pre-Exposure Prophylaxis

Details

Title: Subtitle: Long-acting preexposure prophylaxis in low- and middle-income countries: key considerations for implementation
Creators: Quanhathai Kaewpoowat - Research Institute for Health Sciences
Suwat Chariyalertsak - Chiang Mai University
Nittaya Phanuphak - Institute of HIV Research and Innovation, Bangkok, Thailand
Reshmie A Ramautarsing - Institute of HIV Research and Innovation, Bangkok, Thailand
Resource Type: Journal article
Publication Details: Current opinion in HIV & AIDS, Vol.17(3), pp.135-144
DOI: 10.1097/COH.0000000000000729
PMID: 35439788
ISSN: 1746-630X
eISSN: 1746-6318
Language: English
Date published: 05/01/2022
Academic Unit: Internal Medicine
Record Identifier: 9984359811402771

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