Journal article
Long-term Association of Pericardial Adipose Tissue with Incident Diabetes and Prediabetes: the Coronary Artery Risk Development in Young Adults Study
Epidemiology and health, Vol.45, e2023001
2023
DOI: 10.4178/epih.e2023001
PMCID: PMC10106546
PMID: 36550747
Abstract
We examined if pericardial adipose tissue (PAT) is predictive of prediabetes and type 2 diabetes over time.
A total of 2,570 adults without prediabetes/diabetes from the Coronary Artery Risk Development in Young Adults Study were followed up over 15 years. PAT volume was measured by computed-tomography scans and new onset of prediabetes/diabetes was examined 5, 10, and 15 years after the PAT measurement. Multivariable Cox regression models were used to examine the association between tertile of PAT and up to 15 years later incident prediabetes/diabetes. The predictive ability of PAT (vs. waist circumference (WC), body mass index (BMI), waist-to-height ratio (WHtR)) for prediabetes/diabetes was examined by comparing the receiver operating characteristics curve (ROC)-area under the curve (AUC).
The highest tertile of PAT was associated with 1.56 (95% CI 1.03, 2.34) times higher rate of diabetes than the lowest tertile; however, no association was found between the highest tertile of PAT and prediabetes in the fully adjusted models, including additional adjustment for BMI or WC. In the fully adjusted models, the ROC-AUC of WC, BMI, WHtR, and PAT in predicting diabetes were not significantly different, whereas the ROC-AUC of WC in predicting prediabetes were higher than that of PAT.
PAT may be a significant predictor of hyperglycemia, but this association may be dependent on the effect of BMI or WC. Additional work is warranted to examine if novel adiposity indicators can suggest advanced and optimal information to the established diagnosis for prediabetes/diabetes.
Details
- Title: Subtitle
- Long-term Association of Pericardial Adipose Tissue with Incident Diabetes and Prediabetes: the Coronary Artery Risk Development in Young Adults Study
- Creators
- Minsuk Oh - Baylor UniversityWonhee Cho - Syracuse UniversityDong Hoon Lee - Nanyang Technological UniversityKara M Whitaker - University of IowaPamela J Schreiner - University of MinnesotaJames G Terry - Vanderbilt University Medical CenterJoon Young Kim - Syracuse University
- Resource Type
- Journal article
- Publication Details
- Epidemiology and health, Vol.45, e2023001
- DOI
- 10.4178/epih.e2023001
- PMID
- 36550747
- PMCID
- PMC10106546
- NLM abbreviation
- Epidemiol Health
- ISSN
- 2092-7193
- eISSN
- 2092-7193
- Grant note
- DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100008333, name: University of Alabama at Birmingham, award: HHSN268201800005I, HHSN268201800007I; DOI: 10.13039/100007059, name: Northwestern University, award: HHSN268201800003I; DOI: 10.13039/100007249, name: University of Minnesota, award: HHSN268201800006I; DOI: 10.13039/100007241, name: Kaiser Foundation Research Institute, award: HHSN268201800004I
- Language
- English
- Electronic publication date
- 12/03/2022
- Date published
- 2023
- Academic Unit
- Epidemiology; Health, Sport, and Human Physiology
- Record Identifier
- 9984345164802771
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