Long-term Coarse Particulate Matter Exposure and Heart Rate Variability in the Multi-ethnic Study of Atherosclerosis

Richa Adhikari; Jennifer D'Souza; Elsayed Z Soliman; Gregory L Burke; Martha L Daviglus; David R Jacobs Jr; Sung Kyun Park; Lianne Sheppard; Peter S Thorne; Joel D Kaufman; Timothy V Larson; Sara Dubowsky Adar

doi:10.1097/EDE.0000000000000455

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Long-term Coarse Particulate Matter Exposure and Heart Rate Variability in the Multi-ethnic Study of Atherosclerosis

Journal article

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Long-term Coarse Particulate Matter Exposure and Heart Rate Variability in the Multi-ethnic Study of Atherosclerosis

Richa Adhikari, Jennifer D'Souza, Elsayed Z Soliman, Gregory L Burke, Martha L Daviglus, David R Jacobs Jr, Sung Kyun Park, Lianne Sheppard, Peter S Thorne, Joel D Kaufman, …

Epidemiology (Cambridge, Mass.), Vol.27(3), pp.405-413

05/2016

DOI: 10.1097/EDE.0000000000000455

PMCID: PMC5472334

PMID: 27035690

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Abstract

Reduced heart rate variability, a marker of impaired cardiac autonomic function, has been linked to short-term exposure to airborne particles. This research adds to the literature by examining associations with long-term exposures to coarse particles (PM10-2.5). Using electrocardiogram recordings from 2,780 participants (45-84 years) from three Multi-ethnic Study of Atherosclerosis sites, we assessed the standard deviation of normal to normal intervals and root-mean square differences of successive normal to normal intervals at a baseline (2000-2002) and follow-up (2010-2012) examination (mean visits/person = 1.5). Annual average concentrations of PM10-2.5 mass, copper, zinc, phosphorus, silicon, and endotoxin were estimated using site-specific spatial prediction models. We assessed associations for baseline heart rate variability and rate of change in heart rate variability over time using multivariable mixed models adjusted for time, sociodemographic, lifestyle, health, and neighborhood confounders, including copollutants. In our primary models adjusted for demographic and lifestyle factors and site, PM10-2.5 mass was associated with 1.0% (95% confidence interval [CI]: -4.1, 2.1%) lower standard deviation of normal to normal interval levels per interquartile range of 2 μg/m. Stronger associations, however, were observed before site adjustment and with increasing residential stability. Similar patterns were found for root-mean square differences of successive normal to normal intervals. We found little evidence for associations with other chemical species and with the rate of change in heart rate variability, though endotoxin was associated with increasing heart rate variability over time. We found only weak evidence that long-term PM10-2.5 exposures are associated with lowered heart rate variability. Stronger associations among residentially stable individuals suggest that confirmatory studies are needed.

Autonomic Nervous System Diseases - epidemiology

Multivariate Analysis

Heart Diseases - physiopathology

Humans

Middle Aged

Risk Factors

Male

Autonomic Nervous System Diseases - physiopathology

Heart Diseases - epidemiology

Aged, 80 and over

Electrocardiography

Heart Rate - physiology

Female

Particulate Matter

Aged

Environmental Exposure - statistics & numerical data

Cohort Studies

Details

Title: Subtitle: Long-term Coarse Particulate Matter Exposure and Heart Rate Variability in the Multi-ethnic Study of Atherosclerosis
Creators: Richa Adhikari
Jennifer D'Souza
Elsayed Z Soliman
Gregory L Burke
Martha L Daviglus
David R Jacobs Jr
Sung Kyun Park
Lianne Sheppard
Peter S Thorne
Joel D Kaufman
Timothy V Larson
Sara Dubowsky Adar
Resource Type: Journal article
Publication Details: Epidemiology (Cambridge, Mass.), Vol.27(3), pp.405-413
DOI: 10.1097/EDE.0000000000000455
PMID: 27035690
PMCID: PMC5472334
NLM abbreviation: Epidemiology
ISSN: 1044-3983
eISSN: 1531-5487
Publisher: United States
Grant note: N01HC95169 / NHLBI NIH HHS N01 HC095160 / NHLBI NIH HHS UL1-TR-000040 / NCATS NIH HHS N01HC95161 / NHLBI NIH HHS N01 HC095168 / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS N01 HC095165 / NHLBI NIH HHS P30 DK092926 / NIDDK NIH HHS N01-HC-95169 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS N01 HC095162 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS N01-HC-95166 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS N01 HC095166 / NHLBI NIH HHS N01 HC095163 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS N01-HC-95163 / NHLBI NIH HHS UL1 TR001079 / NCATS NIH HHS P30 ES005605 / NIEHS NIH HHS N01 HC095164 / NHLBI NIH HHS N01-HC-95168 / NHLBI NIH HHS N01-HC-95165 / NHLBI NIH HHS N01-HC-95160 / NHLBI NIH HHS N01 HC095169 / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS N01-HC-95162 / NHLBI NIH HHS UL1-TR-001079 / NCATS NIH HHS P30 DK020572 / NIDDK NIH HHS N01-HC-95159 / NHLBI NIH HHS N01 HC095159 / NHLBI NIH HHS N01 HC095161 / NHLBI NIH HHS N01HC95168 / NHLBI NIH HHS N01-HC-95161 / NHLBI NIH HHS N01-HC-95167 / NHLBI NIH HHS N01-HC-95164 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS N01 HC095167 / NHLBI NIH HHS N01HC95162 / NHLBI NIH HHS
Language: English
Date published: 05/2016
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health
Record Identifier: 9983997999702771

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