Journal article
Long-term dietary intervention influence on physical activity in the Women’s Health Initiative Dietary Modification randomized trial
Breast cancer research and treatment, Vol.195(1), pp.43-54
07/12/2022
DOI: 10.1007/s10549-022-06655-8
Abstract
Purpose
In the Women’s Health Initiative (WHI) Dietary Modification (DM) randomized trial, dietary intervention significantly reduced breast cancer mortality (
P
= 0.02). In observational studies, physical activity is associated with lower breast cancer incidence. Currently, dietary intervention influence on other health-related behaviors is unknown. Therefore, we evaluated whether the WHI dietary intervention influenced self-directed physical activity.
Methods
Of 48,835 postmenopausal women, 19,541 were randomized to dietary intervention (18 nutritionist-led group sessions first year, then quarterly sessions throughout 8.5 years [median] intervention) and 29,294 to a usual diet comparison (written health-related materials only). Neither randomization group received specific or ongoing instructions to increase physical activity. Episodes per week of moderate or vigorous recreational physical activity (MVPA) were serially reported. Marginal longitudinal logistic regression models were used to assess physically inactive (MVPA = 0) or physically active (MVPA > 0) participants by randomization group. Marginal Poisson regression models estimated mean weekly MVPA.
Results
At entry, 45.6% of all participants reported physical inactivity (MVPA = 0). In 43,760 women with MVPA information, throughout 15.9 years (median) cumulative follow-up, dietary intervention group participation was associated with 7% lower physical inactivity rate (odds ratio [OR] 0.93, 95% confidence interval [CI] 0.91, 0.95,
P
< 0.001) and a 4% higher mean MVPA (ratio of means [RM] 1.04 95% CI 1.02, 1.06,
P
< 0.001), relative to the comparison group.
Conclusion
In a randomized trial setting, a low-fat dietary pattern intervention was associated with a long-term, favorable influence on self-directed recreational physical activity.
Trial registration
: NCT00000611.
Details
- Title: Subtitle
- Long-term dietary intervention influence on physical activity in the Women’s Health Initiative Dietary Modification randomized trial
- Creators
- Kathy Pan - Kaiser PermanenteAaron K. Aragaki - Fred Hutch Cancer CenterYvonne Michael - Drexel UniversityCynthia A. Thomson - University of ArizonaLinda G. Snetselaar - University of IowaJean Wactawski-Wende - University at Buffalo, State University of New YorkDavid O. Garcia - Dana-Farber Cancer InstituteChristina M. Dieli-Conwright - Dana-Farber Cancer InstituteAladdin H. Shadyab - Human Longevity (United States)Nazmus Saquib - Sulaiman Al Rajhi CollegesRowan T. Chlebowski - The Lundquist Institute
- Resource Type
- Journal article
- Publication Details
- Breast cancer research and treatment, Vol.195(1), pp.43-54
- DOI
- 10.1007/s10549-022-06655-8
- ISSN
- 0167-6806
- eISSN
- 1573-7217
- Publisher
- Springer US
- Grant note
- N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, and 44221. R25CA203650 / Foundation for the National Institutes of Health (http://dx.doi.org/10.13039/100000009)
- Language
- English
- Date published
- 07/12/2022
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984277452502771
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