Journal article
Long-term disease progression in pediatric acute recurrent and chronic pancreatitis: A report from INSPPIRE
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
02/02/2026
DOI: 10.1016/j.pan.2026.01.076
PMID: 41672858
Abstract
Acute recurrent pancreatitis (ARP) in childhood can rapidly progress to chronic pancreatitis (CP). Prospectively-collected data from the INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE) provides novel insight into disease progression.
INSPPIRE subjects were categorized as persistent ARP (pARP = remained ARP through last follow-up), incident CP (iCP = ARP at enrollment, developed CP), or prevalent CP (pCP = CP at enrollment). Time-to-sequelae and risk factors were analyzed.
Of 626 total children, 384 (61%) were ARP at baseline; of these, 81 (21.1%) were iCP at follow-up.
iCP were more likely to have PRSS1 mutations, obstructive risk factors, and more acute pancreatitis episodes (AP) vs. pARP, but didn’t differ in age at first AP.
Exocrine pancreatic insufficiency (EPI) developed in 24% during follow-up, 10% of pARP, 32% of iCP. In all CP, 50% had EPI by 17.7yrs, median 10yrs after first AP.
Diabetes mellitus (DM) developed in 8% during follow-up, 6% of pARP, 5% of iCP. In all CP, median event-free survival from birth and after first AP was not reached.
Prospective follow-up of children with ARP revealed nearly 1 in 5 progressed to CP, with a subset developing irreversible sequelae, and highlighted risk factors associated with progression including genetics, obstructive disease, and episode frequency.
Details
- Title: Subtitle
- Long-term disease progression in pediatric acute recurrent and chronic pancreatitis: A report from INSPPIRE
- Creators
- Elissa M. Downs - University of MinnesotaEmily R. Perito - University of California, San FranciscoFuchenchu Wang - Anderson University - South CarolinaGretchen A. Cress - University of IowaMaisam Abu-El-Haija - University of Cincinnati Medical CenterAnkur Chugh - Medical College of WisconsinReuven Zev Cohen - Emory UniversityDouglas S. Fishman - Texas Children's HospitalA.Jay Freeman - Nationwide Children's HospitalCheryl E. Gariepy - Nationwide Children's HospitalMatthew J. Giefer - Ochsner Health SystemTanja Y. Gonska - University of TorontoAmit S. Grover - Boston Children's MuseumSohail Z. Husain - Stanford UniversityDouglas Lindblad - University of PittsburghQuin Y. Liu - Cedars-Sinai Medical CenterAsim Maqbool - Children's Hospital of PhiladelphiaJacob A. Mark - University of Colorado SystemBrian A. McFerron - Indiana UniversityMegha S. Mehta - The University of Texas Southwestern Medical CenterVeronique D. Morinville - McGill UniversityKenneth Ng - Johns Hopkins UniversityRobert Adam Noel - Baylor College of MedicineChee Y. Ooi - Sydney Children's HospitalDavid M. Troendle - The University of Texas Southwestern Medical CenterMichael Wilschanski - Hadassah Medical CenterYuhua Zheng - Children's CenterYing Yuan - The University of Texas MD Anderson Cancer CenterMark E. Lowe - Washington University in St. LouisAliye Uc - University of IowaConsortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
- Resource Type
- Journal article
- Publication Details
- Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
- DOI
- 10.1016/j.pan.2026.01.076
- PMID
- 41672858
- NLM abbreviation
- Pancreatology
- ISSN
- 1424-3903
- eISSN
- 1424-3911
- Publisher
- Elsevier B.V
- Language
- English
- Electronic publication date
- 02/02/2026
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9985139468302771
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