Journal article
Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial
Lancet neurology, Vol.18(3), pp.259-268
03/2019
DOI: 10.1016/S1474-4422(18)30392-2
PMCID: PMC6774753
PMID: 30692052
Abstract
The Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone (MGTX) showed that thymectomy combined with prednisone was superior to prednisone alone in improving clinical status as measured by the Quantitative Myasthenia Gravis (QMG) score in patients with generalised non-thymomatous myasthenia gravis at 3 years. We investigated the long-term effects of thymectomy up to 5 years on clinical status, medication requirements, and adverse events.
Details
- Title: Subtitle
- Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial
- Creators
- Gil I Wolfe - Department of Neurology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA. Electronic address: gilwolfe@buffalo.eduHenry J Kaminski - Department of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC, USAInmaculada B Aban - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USAGreg Minisman - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USAHui-Chien Kuo - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USAAlexander Marx - Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, GermanyPhilipp Ströbel - Institute of Pathology, University of Göttingen, Göttingen, GermanyClaudio Mazia - Department of Neurology, University of Buenos Aires, Buenos Aires, ArgentinaJoel Oger - Division of Neurology, University of British Columbia, Vancouver, BC, CanadaJ Gabriel Cea - Department of Neurology, University of Chile, Santiago, ChileJeannine M Heckmann - Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South AfricaAmelia Evoli - Department of Neurology, Catholic University, Rome, ItalyWilfred Nix - Department of Neurology, Johanes Gutenberg University, Mainz, GermanyEmma Ciafaloni - Department of Neurology, University of Rochester Medical Centre, Rochester, NY, USAGiovanni Antonini - Department of Neurology, Mental Health and Sensory Organs, University of Rome Sapienza, Rome, ItalyRawiphan Witoonpanich - Department of Neurology, Mahidol University, Bangkok, ThailandJohn O King - Department of Neurology, University of Melbourne, Melbourne, VIC, AustraliaSaid R Beydoun - Department of Neurology, University of Southern California, Los Angeles, CA, USAColin H Chalk - Department of Neurology, McGill University, Montreal, QC, CanadaAlexandru C Barboi - Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USAAnthony A Amato - Department of Neurology, Harvard Medical School, Boston, MA, USAAziz I Shaibani - Nerve and Muscle Centre of Texas, Houston, TX, USABashar Katirji - Department of Neurology, Case Western Reserve University, Cleveland, OH, USABryan R F Lecky - Walton Centre for Neurology and Neurosurgery, Liverpool, UKCamilla Buckley - Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UKAngela Vincent - Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UKElza Dias-Tosta - Unit of Neurology, Hospital de Base do Distrito Federal, Brasília, BrazilHiroaki Yoshikawa - Department of Neurology, Kanazawa University, Kanazawa, JapanMárcia Waddington-Cruz - Department of Neurology, Federal University, Rio de Janeiro, BrazilMichael T Pulley - Department of Neurology, University of Florida, Jacksonville, FL, USAMichael H Rivner - Department of Neurology, Georgia Regents University, Augusta, GA, USAAnna Kostera-Pruszczyk - Department of Neurology, Medical University of Warsaw, Warsaw, PolandRobert M Pascuzzi - Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USACarlayne E Jackson - Department of Neurology, University of Texas Health Science Centre, San Antonio, TX, USAJan J G M Verschuuren - Department of Neurology, Leiden University Medical Centre, Leiden, NetherlandsJanice M Massey - Department of Neurology, Duke University Medical Centre, Durham, NC, USAJohn T Kissel - Department of Neurology, Ohio State University Wexner Medical Centre, Columbus, OH, USALineu C Werneck - Department of Neurology, Universidade Federal do Parana, Curitiba, BrazilMichael Benatar - Department of Neurology, University of Miami, Miami, FL, USARichard J Barohn - Department of Neurology, University of Kansas Medical Centre, Kansas City, KS, USARup Tandan - Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, VT, USATahseen Mozaffar - Department of Neurology, University of California, Irvine, Orange, CA, USANicholas J Silvestri - Department of Neurology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USARobin Conwit - Division of Extramural Research, National Institutes of Health/National Institute of Neurological Disorders and Stroke, Bethesda, MD, USAJoshua R Sonett - Section of General Thoracic Surgery, Columbia University Medical Centre, New York, NY, USAAlfred Jaretzki III - Section of General Thoracic Surgery, Columbia University Medical Centre, New York, NY, USAJohn Newsom-Davis - Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UKGary R Cutter - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USAMGTX Study Group
- Contributors
- Laurie Gutmann (Contributor) - University of Iowa, Neurology
- Resource Type
- Journal article
- Publication Details
- Lancet neurology, Vol.18(3), pp.259-268
- DOI
- 10.1016/S1474-4422(18)30392-2
- PMID
- 30692052
- PMCID
- PMC6774753
- NLM abbreviation
- Lancet Neurol
- ISSN
- 1474-4422
- eISSN
- 1474-4465
- Publisher
- England
- Grant note
- U01 NS042685 / NINDS NIH HHS
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Neurology
- Record Identifier
- 9984013163302771
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