Journal article
Long-term effects of culture of preimplantation mouse embryos on behavior
Proceedings of the National Academy of Sciences - PNAS, Vol.101(6), pp.1595-1600
02/10/2004
DOI: 10.1073/pnas.0306846101
PMCID: PMC341785
PMID: 14747652
Abstract
Many procedures used in assisted reproductive technologies (ART) to treat human infertility entail culture of preimplantation embryos. Moreover, there is an increasing trend to culture embryos for longer periods of time before uterine transfer to identify the “best” embryos for transfer and to minimize multiple pregnancies. Embryo culture, however, can perturb embryo metabolism and gene expression, and the long-term consequences of culture are unknown. We have explored the behavioral consequences of embryo culture by using a 129S6/SvEvTac/C57BL/6J F
1
mouse model and find that adults derived from cultured embryos exhibit specific behavioral alterations in the elevated zero maze and Morris water maze tasks.
Details
- Title: Subtitle
- Long-term effects of culture of preimplantation mouse embryos on behavior
- Creators
- David J Ecker - Departments ofPaula Stein - Departments ofZhe Xu - Departments ofCarmen J Williams - Departments ofGregory S Kopf - Departments ofWarren B Bilker - Departments ofTed Abel - Departments ofRichard M Schultz - Departments of
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.101(6), pp.1595-1600
- DOI
- 10.1073/pnas.0306846101
- PMID
- 14747652
- PMCID
- PMC341785
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Language
- English
- Date published
- 02/10/2004
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065827302771
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