Journal article
Long-term effects of overfeeding during lactation on insulin secretion ― the role of GLUT-2
The Journal of nutritional biochemistry, Vol.20(6), pp.435-442
06/01/2009
DOI: 10.1016/j.jnutbio.2008.05.002
PMID: 18708286
Abstract
Overnutrition during critical developmental periods is believed to be a risk factor for the emergence of metabolic disorders in adulthood. The present study investigated the effects of pups overfeeding during lactation on offspring's insulin secretion. To study the consequences of overnutrition early in life in rats, litter size reduction has been shown to be an appropriate experimental model. To induce early postnatal overnutrition, litter size was reduced to three pups per litter at the third day following birth [overfed group (OG)]. In the control group (CG), the litter size was adjusted to 10 pups per litter. Metabolic parameters and glucose-stimulated insulin secretion were assessed. OG pups ingested more milk at 10 and 21 days and had an augmented food intake at 1 year compared to the CG. Consistently, body weight, body fat, and fasting plasma levels of insulin were higher in 1-year-old OG rats. In addition, OG rats exhibited enhanced insulin secretion, accompanied by elevated content of GLUT-2 in pancreatic islets compared to CG. These findings indicate that early postnatal overnutrition during a critical developmental period in life may program permanent alterations in glucose-stimulated insulin secretion.
Details
- Title: Subtitle
- Long-term effects of overfeeding during lactation on insulin secretion ― the role of GLUT-2
- Creators
- Alessandra CORDEIRO DE SOUZA RODRIGUES CUNHA - Departament of Physiological Sciences, State University of Rio de Janeiro, 20550-030 Rio de Janeiro, BrazilRenata Oliveira Pereira - Departament of Physiological Sciences, State University of Rio de Janeiro, 20550-030 Rio de Janeiro, BrazilMario José DOS SANTOS PEREIRA - Universidade do Estado do Rio de JaneiroVivian DE MELO SOARES - Universidade do Estado do Rio de JaneiroMariana RENOVATO MARTINS - Departament of Physiological Sciences, State University of Rio de Janeiro, 20550-030 Rio de Janeiro, BrazilMichelle Teixeira Teixeira - Universidade do Estado do Rio de JaneiroErica Patricia GARCIA SOUZA - Departament of Physiological Sciences, State University of Rio de Janeiro, 20550-030 Rio de Janeiro, BrazilAnibal SANCHEZ MOURA - Departament of Physiological Sciences, State University of Rio de Janeiro, 20550-030 Rio de Janeiro, Brazil
- Resource Type
- Journal article
- Publication Details
- The Journal of nutritional biochemistry, Vol.20(6), pp.435-442
- Publisher
- Elsevier
- DOI
- 10.1016/j.jnutbio.2008.05.002
- PMID
- 18708286
- ISSN
- 0955-2863
- eISSN
- 1873-4847
- Language
- English
- Date published
- 06/01/2009
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984420847402771
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