Journal article
Long-term efficacy and safety of questionnaire-based initiation of urgency urinary incontinence treatment
American journal of obstetrics and gynecology, Vol.209(3), pp.244.e1-244.e9
09/2013
DOI: 10.1016/j.ajog.2013.05.008
PMCID: PMC4019400
PMID: 23659987
Abstract
The objective of the study was to determine the longer-term efficacy and safety of initiating treatment for urgency-predominant urinary incontinence (UUI) in women diagnosed using a simple questionnaire rather than an extensive evaluation.
Women completing a 12 week randomized controlled trial of fesoterodine therapy for UUI diagnosed by questionnaire were invited to participate in a 9 month, open-label continuation study. UUI and voiding episodes were collected using voiding diaries. Participant satisfaction was measured by questionnaire. Safety was assessed by the measurement of postvoid residual volume and adverse event monitoring; if necessary, women underwent a specialist evaluation. The longitudinal changes in UUI and voiding episodes were evaluated using linear mixed models adjusting for baseline.
Of the 567 women completing the randomized trial, 498 (87.8%) took at least 1 dose of medication during this open-label study. Compared with the baseline visit in the randomized trial, fesoterodine was associated with a reduction in total incontinence episodes per day and urgency incontinence episodes per day at the end of the open-label study (adjusted mean [SE], 4.6 [0.12] to 1.2 [0.13] and 3.9 [0.11] to 0.9 [0.11], respectively, P < .0001 for both). Most women were satisfied with treatment (89%, 92%, and 93% at 3, 6, and 9 months, respectively). Twenty-six women experienced 28 serious adverse events, 1 of which was considered possibly treatment related. Twenty-two women had a specialist evaluation: 5 women's incontinence was misclassified by the 3 Incontinence Questions; none experienced harm because of misclassification.
Using a simple validated questionnaire to diagnose and initiate treatment for UUI in community-dwelling women is safe and effective, allowing timely treatment by primary care practitioners.
Details
- Title: Subtitle
- Long-term efficacy and safety of questionnaire-based initiation of urgency urinary incontinence treatment
- Creators
- Rachel Hess - University of PittsburghAlison J. Huang - University of California, San FranciscoHolly E. Richter - University of Alabama at BirminghamChiara C. Ghetti - University of PittsburghVivian W. Sung - Brown UniversityElizabeth Barrett-Connor - University of California, San DiegoW. Thomas Gregory - Oregon Health & Science UniversityJoAnn V. Pinkerton - University of VirginiaCatherine S. Bradley - University of IowaStephen R. Kraus - The University of Texas Health Science Center at San AntonioRebecca G. Rogers - University of New MexicoLeslee L. Subak - University of California, San FranciscoKaren C. Johnson - University of Tennessee Health Science CenterLily A. Arya - Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PAMichael Schembri - University of California, San FranciscoJeanette S. Brown - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.209(3), pp.244.e1-244.e9
- Publisher
- Mosby, Inc
- DOI
- 10.1016/j.ajog.2013.05.008
- PMID
- 23659987
- PMCID
- PMC4019400
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Grant note
- Bionovo and Endoceutics Pfizer, Noven Pharmaceuticals, Shionogi, and DepoMed Pfizer, Inc American Medical Systems Astellas
- Language
- English
- Date published
- 09/2013
- Academic Unit
- Epidemiology; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984315748202771
Metrics
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