Journal article
Long-term evaluation of the stability of dentin matrix following treatments with aqueous solutions of titanium tetrafluoride at different concentrations
Archives of oral biology, Vol.91, pp.51-56
07/2018
DOI: 10.1016/j.archoralbio.2018.04.006
PMID: 29673998
Abstract
•Aqueous solution of 2.5% TiF4 increases immediate stiffness values of the demineralized dentin matrix.•Aqueous solutions of 2.5% TiF4 increased protection against exogenous proteases.•Aqueous solutions of 2.5% TiF4 do not stabilize collagenous dentin matrix over time.
The purpose of this study was to investigate the effects of aqueous solutions of different concentrations of titanium tetrafluoride (TiF4) on dentin matrix stability up to six months.
Dentin specimens prepared from fifteen nonerupted molars were demineralized and randomly distributed into groups: 2.5% TiF4, 4% TiF4, 1000 ppm NaF, and control (distilled water). The modulus of elasticity (ME) and dry masses of the dentin matrix were determined at baseline, and up to 6 months following treatment. Collagen solubilization was estimated by hydroxyproline (HYP) quantification in the simulated body fluid used to store the dentin specimens.
The 2.5% TiF4 group presented higher ME immediately after treatment, and at 3 and 6 months storage, whereas 4% TiF4 showed higher means at 3 and 6 months (p < 0.001). No significant differences were observed among the groups over time (p = 0.9325). However, the 2.5% TiF4 group showed significantly higher ME than the control group, immediately after treatment. All the groups presented significantly higher mass change immediately, compared with 3 and 6 months (p < 0.0001). Except for the 4% TiF4 group, HYP release was higher in the first quarter (p = 0.0152), when no significant differences were found among the groups. In the second quarter, the means were significantly higher in the 2.5% TiF4 and 4% TiF4 groups. The group treated with 2.5% TiF4 had a statistically higher HYP release than the control group.
An aqueous solution of 2.5% TiF4 increases the immediate stiffness values, but does not stabilize the collagenous dentin matrix.
Details
- Title: Subtitle
- Long-term evaluation of the stability of dentin matrix following treatments with aqueous solutions of titanium tetrafluoride at different concentrations
- Creators
- E.C. Bridi - Faculdade São Leopoldo MandicA.A. Leme-Kraus - University of Illinois at ChicagoB. Aydin - University of Illinois at ChicagoR.T. Basting - Faculdade São Leopoldo MandicA.K. Bedran-Russo - University of Illinois at Chicago
- Resource Type
- Journal article
- Publication Details
- Archives of oral biology, Vol.91, pp.51-56
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.archoralbio.2018.04.006
- PMID
- 29673998
- ISSN
- 0003-9969
- eISSN
- 1879-1506
- Grant note
- name: São Paulo State Foundation for Research Support FAPESP, award: 2014/18848-9
- Language
- English
- Date published
- 07/2018
- Academic Unit
- Operative Dentistry
- Record Identifier
- 9984367639402771
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