Journal article
Long-term follow up of rates of secondary malignancy and late relapse of two trials using radioimmunotherapy consolidation following induction chemotherapy for previously untreated indolent lymphoma
Leukemia & lymphoma, Vol.56(10), pp.2870-2875
10/03/2015
DOI: 10.3109/10428194.2015.1016929
PMID: 25676037
Abstract
Existing data suggest that myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) peak in incidence 5-10 years following exposure to ionizing radiation, while most publications report less than 5 years of follow-up after radioimmunotherapy (RIT). We report the rate of secondary MDS/AML among 60 patients treated with two front-line sequential chemotherapy-RIT trials with over 11 years of follow-up. Among 35 patients evaluated after fludarabine-RIT and 25 patients evaluated after CVP (cyclophosphamide, vincristine, prednisone)-RIT treatment, the crude, cumulative and Kaplan-Meier rates of MDS/AML at 11 years of follow-up from the combined trials were 0.12/person, 0.010/person-year and 14% (95% confidence interval [CI] 5-24%), respectively. Additionally, we found that patients treated with RIT consolidation appear to have durable remissions but that relapses after 10 years do occur. Studies of efficacy and secondary MDS/AML that report fewer than 10 years of follow-up likely underestimate risk.
Details
- Title: Subtitle
- Long-term follow up of rates of secondary malignancy and late relapse of two trials using radioimmunotherapy consolidation following induction chemotherapy for previously untreated indolent lymphoma
- Creators
- Jonathan Reiss - Center for Lymphoma and Myeloma, Division of Hematology/Oncology, Weill Cornell Medical CollegeBrian Link - University of Iowa Hospitals and ClinicsJia Ruan - Center for Lymphoma and Myeloma, Division of Hematology/Oncology, Weill Cornell Medical CollegeRichard Furman - Center for Lymphoma and Myeloma, Division of Hematology/Oncology, Weill Cornell Medical CollegeMorton Coleman - Center for Lymphoma and Myeloma, Division of Hematology/Oncology, Weill Cornell Medical CollegeJohn Leonard - Center for Lymphoma and Myeloma, Division of Hematology/Oncology, Weill Cornell Medical CollegePeter Martin - Center for Lymphoma and Myeloma, Division of Hematology/Oncology, Weill Cornell Medical College
- Resource Type
- Journal article
- Publication Details
- Leukemia & lymphoma, Vol.56(10), pp.2870-2875
- Publisher
- Taylor & Francis
- DOI
- 10.3109/10428194.2015.1016929
- PMID
- 25676037
- ISSN
- 1042-8194
- eISSN
- 1029-2403
- Language
- English
- Date published
- 10/03/2015
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094545502771
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