Journal article
Long term follow up study of survival associated with cleft lip and palate at birth
BMJ : British Medical Journal, Vol.328(7453), pp.1405-1405
06/12/2004
DOI: 10.1136/bmj.38106.559120.7C
PMCID: PMC421777
PMID: 15145797
Abstract
Objective
To assess the overall and cause specific mortality of people from birth to 55 years with cleft lip and palate.
Design
Long term follow up study.
Setting
Danish register of deaths.
Participants
People born with cleft lip and palate between 1943 and 1987, followed to 1998.
Main outcome measures
Observed and expected numbers of deaths, summarised as overall and cause specific standardised mortality ratios.
Results
5331 people with cleft lip and palate were followed for 170 421 person years. The expected number of deaths was 259, but 402 occurred, corresponding to a standardised mortality ratio of 1.4 (95% confidence interval 1.3 to 1.6) for males and 1.8 (1.5 to 2.1) for females. The increased risk of mortality was nearly constant for the three intervals at follow up: first year of life, 1-17 years, and 18-55 years. The participants had an increased risk of all major causes of death.
Conclusions
People with cleft lip and palate have increased mortality up to age 55. Children born with cleft lip and palate and possibly other congenital malformations may benefit from specific preventive health measures into and throughout adulthood.
Details
- Title: Subtitle
- Long term follow up study of survival associated with cleft lip and palate at birth
- Creators
- Kaare Christensen - Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, DK-5000 Odense, DenmarkKnud Juel - National Institute of Public Health, DK-2100 Copenhagen, DenmarkAnne Maria Herskind - Odense University Hospital, Department of Pediatrics, DK-5000 Odense, DenmarkJeffrey C Murray - University of Iowa, Department of Pediatrics, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- BMJ : British Medical Journal, Vol.328(7453), pp.1405-1405
- DOI
- 10.1136/bmj.38106.559120.7C
- PMID
- 15145797
- PMCID
- PMC421777
- NLM abbreviation
- BMJ
- ISSN
- 0959-8138
- eISSN
- 1468-5833
- Publisher
- BMJ Publishing Group Ltd
- Language
- English
- Date published
- 06/12/2004
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025369302771
Metrics
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