Journal article
Long-term followup of rheumatoid arthritis patients treated with total lymphoid irradiation
Arthritis and rheumatism, Vol.30(1), pp.1-10
1987
DOI: 10.1002/art.1780300101
PMID: 2949753
Abstract
Total lymphoid irradiation was administered to 32 patients with intractable rheumatoid arthritis. Twenty-four patients showed at least a 25% improvement in 3 of 4 disease activity parameters, which persisted during the followup period of up to 48 months. Eight of the 32 patients required adjunctive immunosuppressive drug therapy to maintain improvement. Four patients died after total lymphoid irradiation; the causes of death were acute myocardial infarction (1 patient), pulmonary embolism (1 patient), and rheumatoid lung disease complicated by respiratory infection (2 patients). After therapy, patients exhibited a prolonged reduction in the number and function of circulating T helper cells.
Details
- Title: Subtitle
- Long-term followup of rheumatoid arthritis patients treated with total lymphoid irradiation
- Creators
- A TANAY - Stanford univ. school medicine, dep. medicine, Stanford CA 94305, United StatesE. H FIELD - Stanford univ. school medicine, dep. medicine, Stanford CA 94305, United StatesR. T HOPPE - Stanford univ. school medicine, dep. medicine, Stanford CA 94305, United StatesS STROBER - Stanford univ. school medicine, dep. medicine, Stanford CA 94305, United States
- Resource Type
- Journal article
- Publication Details
- Arthritis and rheumatism, Vol.30(1), pp.1-10
- DOI
- 10.1002/art.1780300101
- PMID
- 2949753
- NLM abbreviation
- Arthritis Rheum
- ISSN
- 0004-3591
- eISSN
- 1529-0131
- Publisher
- Wiley
- Language
- English
- Date published
- 1987
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094765902771
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