Long-term functional and quality of life outcomes after coloanal anastomosis for distal rectal cancer

Imran HASSAN; David W LARSON; John H PEMBERTON; Robert R CIMA; Janette U GAW; Heidi K CHUA; Dieter HAHNLOSER; John M STULAK; Megan M O'BYRNE; Dirk R LARSON; Bruce G WOLFF

doi:10.1007/s10350-006-0640-0

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Long-term functional and quality of life outcomes after coloanal anastomosis for distal rectal cancer

Journal article

Peer reviewed

Long-term functional and quality of life outcomes after coloanal anastomosis for distal rectal cancer

Imran HASSAN, David W LARSON, John H PEMBERTON, Robert R CIMA, Janette U GAW, Heidi K CHUA, Dieter HAHNLOSER, John M STULAK, Megan M O'BYRNE, Dirk R LARSON, …

Diseases of the colon & rectum, Vol.49(9), pp.1266-1274

2006

DOI: 10.1007/s10350-006-0640-0

PMID: 16915510

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Abstract

Purpose: This study was designed to evaluate the long-term functional and quality-of-life outcomes of patients after coloanal anastomosis for distal rectal cancer. Methods: A total of 192 patients underwent coloanal anastomosis between 1982 and 2001 at two tertiary referral institutions. Standardized and validated questionnaires to assess functional and quality-of-life outcomes were mailed to 151 patients, of which 121 patients responded (median follow-up, 65 months). Results: Patients receiving pelvic radiotherapy had more bowel function problems than patients who did not receive pelvic radiotherapy. No significant differences in relevant functional and quality-of-life outcomes were seen among patients who received preoperative or postoperative pelvic radiotherapy. Patients requiring permanent diversion as a result of complications of the surgery had decreased quality of life. Conclusions: Coloanal anastomosis for distal rectal cancer has favorable long-term outcomes. Pelvic radiotherapy has an adverse effect on subsequent bowel function (whether given preoperatively or postoperatively) in patients who maintain intestinal continuity. Loss of intestinal continuity after a coloanal anastomosis is associated with diminished quality of life.

Tumors

Gastroenterology. Liver. Pancreas. Abdomen

Stomach. Duodenum. Small intestine. Colon. Rectum. Anus

Biological and medical sciences

Medical sciences

Details

Title: Subtitle: Long-term functional and quality of life outcomes after coloanal anastomosis for distal rectal cancer
Creators: Imran HASSAN - Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, United States
David W LARSON - Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, United States
John H PEMBERTON - Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, United States
Robert R CIMA - Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, United States
Janette U GAW - Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, United States
Heidi K CHUA - Division of Colon and Rectal Surgery, Mayo Clinic, Jacksonville, Florida, United States
Dieter HAHNLOSER - Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, United States
John M STULAK - Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, United States
Megan M O'BYRNE - Division of Biostatistics, Mayo Clinic, Rochester, Minnesota, United States
Dirk R LARSON - Division of Biostatistics, Mayo Clinic, Rochester, Minnesota, United States
Bruce G WOLFF - Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, United States
Resource Type: Journal article
Publication Details: Diseases of the colon & rectum, Vol.49(9), pp.1266-1274
Publisher: Springer; Secaucus, NJ
DOI: 10.1007/s10350-006-0640-0
PMID: 16915510
ISSN: 0012-3706
eISSN: 1530-0358
Language: English
Date published: 2006
Academic Unit: Surgery
Record Identifier: 9984051789602771

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