Journal article
Long-term mortality and quality of life in sepsis: A systematic review
Critical care medicine, Vol.38(5), pp.1276-1283
2010
DOI: 10.1097/CCM.0b013e3181d8cc1d
PMID: 20308885
Abstract
Background: Long-term outcomes from sepsis are poorly understood, and sepsis in patients may have different long-term effects on mortality and quality of life. Long-term outcome studies of other critical illnesses such as acute lung injury have demonstrated incremental health effects that persist after hospital discharge. Whether patients with sepsis have similar long-term mortality and quality-of-life effects is unclear.
Objective: We performed a systematic review of studies reporting long-term mortality and quality-of-life data (>3 months) in patients with sepsis, severe sepsis, and septic shock using defined search criteria.
Design: Systematic review of the literature.
Interventions: None.
Main results: Patients with sepsis showed ongoing mortality up to 2 yrs and beyond after the standard 28-day inhospital mortality end point. Patients with sepsis also had decrements in quality-of-life measures after hospital discharge. Results were consistent across varying severity of illness and different patient populations in different countries, including large and small studies. In addition, these results were consistent within observational and randomized, controlled trials. Study quality was limited by inadequate control groups and poor adjustment for confounding variables.
Conclusions: Patients with sepsis have ongoing mortality beyond short-term end points, and survivors consistently demonstrate impaired quality of life. The use of 28-day mortality as an end point for clinical studies may lead to inaccurate inferences. Both observational and interventional future studies should include longer-term end points to better-understand the natural history of sepsis and the effect of interventions on patient morbidities.
Details
- Title: Subtitle
- Long-term mortality and quality of life in sepsis: A systematic review
- Creators
- Bradford D WINTERS - Departments of Anesthesiology and Critical Care Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesMichael EBERLEIN - Critical Care Physical Medicine & Rehabilitation Program, Johns Hopkins University, Baltimore, MD, United StatesJanice LEUNG - Departments of Anesthesiology and Critical Care Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDale M NEEDHAM - National Institutes of Health, Bethesda, MD, United StatesPeter J PRONOVOST - Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesJonathan E SEVRANSKY - Johns Hopkins University, Baltimore, MD, United States
- Resource Type
- Journal article
- Publication Details
- Critical care medicine, Vol.38(5), pp.1276-1283
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/CCM.0b013e3181d8cc1d
- PMID
- 20308885
- ISSN
- 0090-3493
- eISSN
- 1530-0293
- Language
- English
- Date published
- 2010
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094738502771
Metrics
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