Journal article
Long-term outcome comparison for standard fractionation (>= 59 Gy) versus hyperfractionated (>= 45 Gy) radiotherapy plus concurrent C chemotherapy for limited-stage small-cell lung cancer
Reports of practical oncology and radiotherapy, Vol.25(4), pp.489-493
07/01/2020
DOI: 10.1016/j.rpor.2020.03.017
PMCID: PMC7251533
PMID: 32477014
Abstract
Background: Concurrent chemoradiotherapy (CCRT) is commonly employed in limited-stage small-cell lung cancer (LS-SCLC); however, the optimal radiotherapy regimen is still unknown. This 3-institution analysis compares long-term disease control and survival outcomes for once- (QD) versus twice-daily (BID) radiotherapy at contemporary doses.
Methods and Materials: Data were collected for LS-SCLC patients treated with platinum-based CCRT and planned RT doses of >= 5940 cGy at >= 180 cGy QD or >= 4500 cGy at 150 cGy BID. Comparative outcome analyses were performed for treatment groups.
Results: From 2005 through 2014, 132 patients met inclusion criteria for analysis (80 QD, 52 BID). Treatment groups were well-balanced, excepting higher rate of advanced mediastinal staging, longer interval from biopsy to treatment initiation, and lower rate of prophylactic cranial irradiation for the QD group, as well as institutional practice variation. At median survivor follow-up of 33.5 months (range, 4.6-105.8), 80 patients experienced disease failure (44 QD, 36 BID), and 106 died (62 QD, 44 BID). No differences in disease control or survival were demonstrated between treatment groups.
Conclusion: The present analysis did not detect a difference in disease control or survival outcomes for contemporary dose QD versus BID CCRT in LS-SCLC. (C) 2020 Greater Poland Cancer Centre. Published by Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Long-term outcome comparison for standard fractionation (>= 59 Gy) versus hyperfractionated (>= 45 Gy) radiotherapy plus concurrent C chemotherapy for limited-stage small-cell lung cancer
- Creators
- John M. Watkins - Bismarck State CollegeJ. Kyle Russo - Bismarck State CollegeNicholas Andresen - Johns Hopkins HospitalCoyt R. Rountree - Medical University of South CarolinaAmir Zahra - University of IowaSarah L. Mott - University of IowaDaniel J. Herr - Medical University of South CarolinaJacy O'Keefe - Bismarck Canc Ctr, Bismarck, ND 58501 USABryan G. Allen - University of IowaAnand K. Sharma - Medical University of South CarolinaJohn M. Buatti - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Reports of practical oncology and radiotherapy, Vol.25(4), pp.489-493
- DOI
- 10.1016/j.rpor.2020.03.017
- PMID
- 32477014
- PMCID
- PMC7251533
- NLM abbreviation
- Rep Pract Oncol Radiother
- ISSN
- 1507-1367
- eISSN
- 2083-4640
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- P50 CA174521; P30 CA086862 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 07/01/2020
- Academic Unit
- Radiation Oncology; Neurosurgery; Otolaryngology
- Record Identifier
- 9984303901402771
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