Journal article
Long-term prognosis of bipolar I disorder
Acta psychiatrica Scandinavica, Vol.99(2), pp.110-119
02/1999
DOI: 10.1111/j.1600-0447.1999.tb07208.x
PMID: 10082186
Abstract
This study examined the contribution of demographic, syndromal and longitudinal course variables to the long-term prognosis of 165 bipolar patients prospectively observed over 10 years as part of the National Institute of Mental Health Collaborative Study of Depression. Although most baseline clinical and demographic variables were not strong prognostic indicators, switching polarity within episodes was. Most episodes among the poor-prognosis patients were polyphasic, while most episodes among the comparison group with a better prognosis were monophasic. There was no evidence of shortening of cycle lengths over follow-up for either the poor-prognosis group or the entire sample. The relevance of these findings to the 'kindling' model is discussed.
Details
- Title: Subtitle
- Long-term prognosis of bipolar I disorder
- Creators
- C L Turvey - Department of Psychiatry, University of Iowa, Iowa City 52242-1000, USAW H CoryellD A SolomonA C LeonJ EndicottM B KellerH Akiskal
- Resource Type
- Journal article
- Publication Details
- Acta psychiatrica Scandinavica, Vol.99(2), pp.110-119
- Publisher
- United States
- DOI
- 10.1111/j.1600-0447.1999.tb07208.x
- PMID
- 10082186
- ISSN
- 0001-690X
- eISSN
- 1600-0447
- Grant note
- R01 MH025478 / NIMH NIH HHS
- Language
- English
- Date published
- 02/1999
- Academic Unit
- Psychiatry; Epidemiology
- Record Identifier
- 9984003986102771
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