Long-term quality of life for surgical and nonsurgical treatment of head and neck cancer

Mark El-Deiry; Gerry F Funk; Sarvi Nalwa; Lucy H Karnell; Russell B Smith; John M Buatti; Henry T Hoffman; Gerry H Clamon; Scott M Graham; Douglas K Trask; Kenneth J Dornfeld; Min Yao

doi:10.1001/archotol.131.10.879

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Long-term quality of life for surgical and nonsurgical treatment of head and neck cancer

Journal article

Open access

Peer reviewed

Long-term quality of life for surgical and nonsurgical treatment of head and neck cancer

Mark El-Deiry, Gerry F Funk, Sarvi Nalwa, Lucy H Karnell, Russell B Smith, John M Buatti, Henry T Hoffman, Gerry H Clamon, Scott M Graham, Douglas K Trask, …

Archives of otolaryngology--head & neck surgery, Vol.131(10), pp.879-885

10/2005

DOI: 10.1001/archotol.131.10.879

PMID: 16230590

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Abstract

To compare the long-term, health-related quality-of-life outcomes in patients with advanced head and neck cancer (HNC) treated with surgery and postoperative radiation therapy (SRT) or concurrent chemotherapy and radiation therapy (CRT). Matched-pair study comparing patients with advanced HNC treated with SRT or CRT at least 12 months after treatment. Patients completed 2 validated surveys addressing HNC-specific outcomes and depressive symptoms and provided information on employment and tobacco and alcohol use. Results for the 2 groups were compared using paired-sample t test and chi2 analysis. University-based study. Patients with stage III or IV squamous cell carcinoma of the oropharynx, hypopharynx, and larynx who underwent SRT or received CRT. Head and neck cancer-specific health-related quality of life from the Head and Neck Cancer Inventory and level of depressive symptoms from the Beck Depression Inventory. The matching process resulted in 27 patients in each treatment group. The HNC-specific domain scores (with higher scores representing better outcomes) for CRT vs SRT were eating, 37.8 vs 40.8 (P = .69); speech, 65.1 vs 56.0 (P = .23); aesthetics, 80.3 vs 69.2 (P = .14); and social disruption, 69.7 vs 70.6 (P = .90). Overall health-related quality of life was 64.0 with SRT and 55.0 with CRT (P = .142). For the Beck Depression Inventory (with higher scores representing worse outcomes), patients who underwent SRT had a mean score of 9.6 compared with 11.6 for patients who received CRT (P = .42). As nonsurgical means of treating HNC have become more aggressive and surgical techniques have become more focused on function preservation and rehabilitation, the overall health-related quality of life resulting from these different approaches is similar.

Laryngeal Neoplasms - radiotherapy

Hypopharyngeal Neoplasms - surgery

Pharyngeal Neoplasms - radiotherapy

Oropharyngeal Neoplasms - drug therapy

Laryngeal Neoplasms - surgery

Health Status Indicators

Humans

Middle Aged

Head and Neck Neoplasms - drug therapy

Pharyngeal Neoplasms - surgery

Male

Oropharyngeal Neoplasms - radiotherapy

Combined Modality Therapy

Pharyngeal Neoplasms - drug therapy

Head and Neck Neoplasms - radiotherapy

Hypopharyngeal Neoplasms - radiotherapy

Oropharyngeal Neoplasms - surgery

Laryngeal Neoplasms - drug therapy

Quality of Life

Female

Hypopharyngeal Neoplasms - drug therapy

Head and Neck Neoplasms - surgery

Speech, Alaryngeal

Details

Title: Subtitle: Long-term quality of life for surgical and nonsurgical treatment of head and neck cancer
Creators: Mark El-Deiry - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City 52242-1093, USA
Gerry F Funk
Sarvi Nalwa
Lucy H Karnell
Russell B Smith
John M Buatti
Henry T Hoffman
Gerry H Clamon
Scott M Graham
Douglas K Trask
Kenneth J Dornfeld
Min Yao
Resource Type: Journal article
Publication Details: Archives of otolaryngology--head & neck surgery, Vol.131(10), pp.879-885
DOI: 10.1001/archotol.131.10.879
PMID: 16230590
NLM abbreviation: Arch Otolaryngol Head Neck Surg
ISSN: 0886-4470
eISSN: 1538-361X
Publisher: American Medical Association; United States
Grant note: R01CA106908-01 / NCI NIH HHS
Language: English
Date published: 10/2005
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Radiation Oncology; Neurosurgery; Otolaryngology; Internal Medicine
Record Identifier: 9984006335202771

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