Journal article
Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle
Biochemical Society transactions, Vol.31(1), pp.182-185
02/01/2003
DOI: 10.1042/bst0310182
PMID: 12546681
Abstract
Evidence is accumulating for roles of AMP-activated protein kinase (AMPK) in controlling glucose uptake, fatty acid oxidation and gene expression in skeletal muscle. Relatively little is known, however, about the control of expression of the AMPK subunit isoforms. Marked differences are noted in subunit expression as a function of muscle fibre type. Expression of the γ3 subunit isoform increases in fast-twitch red fibres of the rat in response to training. All subunit isoforms are expressed to a lesser extent in rats treated with propylthiouracil (PTU; an inhibitor of thyroid hormone synthesis) for 3 weeks compared with rats given excess thyroid hormones for 3 weeks. An approx. 2-fold increase in acetyl-CoA carboxylase was observed in gastrocnemius of hyperthyroid rats compared with experimentally hypothyroid rats. Thyroid state therefore appears to be one important factor controlling expression of these proteins in skeletal muscle.
Details
- Title: Subtitle
- Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle
- Creators
- W.W Winder - Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.AD.G Hardie - Division of Molecular Physiology, Dundee University, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, Scotland, U.KK.J Mustard - Division of Molecular Physiology, Dundee University, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, Scotland, U.KL.J Greenwood - Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.AB.E Paxton - Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.AS.H Park - Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.AD.S Rubink - Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.AE.B Taylor - Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.A
- Resource Type
- Journal article
- Publication Details
- Biochemical Society transactions, Vol.31(1), pp.182-185
- DOI
- 10.1042/bst0310182
- PMID
- 12546681
- ISSN
- 0300-5127
- eISSN
- 1470-8752
- Language
- English
- Date published
- 02/01/2003
- Academic Unit
- Molecular Physiology and Biophysics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984025400902771
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