Journal article
Long-term risk of type 2 diabetes in relation to habitual iron intake in women with a history of gestational diabetes: a prospective cohort study
The American journal of clinical nutrition, Vol.103(2), pp.375-381
02/2016
DOI: 10.3945/ajcn.115.108712
PMCID: PMC4733253
PMID: 26762369
Abstract
An iron overload may induce pancreatic islet damage and increase risk of diabetes. Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mellitus (T2DM) after pregnancy.
We aimed to examine the association of habitual iron intake with long-term risk of T2DM in this high-risk population.
We included 3976 women with a history of GDM from the Nurses' Health Study II cohort as part of the ongoing Diabetes & Women's Health Study. The women were followed up through 2009. Iron intake was assessed with the use of a validated food-frequency questionnaire in 1991 and every 4 y thereafter. We used Cox proportional hazards models to estimate HRs and 95% CIs.
We documented 641 incident T2DM cases during 57,683 person-years of observation. Adjusted HRs for T2DM for the highest quartile compared with the lowest quartile were 1.64 (95% CI: 1.20, 2.25; P-trend = 0.02) for total iron intake and 1.80 (95% CI: 1.18, 2.74; P-trend = 0.005) for dietary heme iron intake. In addition, women who consumed ≥30.0 mg supplemental Fe/d, compared with nonusers, had an adjusted HR of 1.83 (95% CI: 1.25, 2.70; P-trend = 0.002).
In women with a history of GDM, greater intakes of total iron, dietary heme iron, and supplemental iron were associated with higher risk of T2DM.
Details
- Title: Subtitle
- Long-term risk of type 2 diabetes in relation to habitual iron intake in women with a history of gestational diabetes: a prospective cohort study
- Creators
- Wei Bao - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDJorge E Chavarro - Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, andDeirdre K Tobias - Epidemiology, Harvard School of Public Health, Boston, MA; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; andKatherine Bowers - Division of Biostatistics and Epidemiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OHShanshan Li - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDFrank B Hu - Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, andCuilin Zhang - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MD; zhangcu@mail.nih.gov
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.103(2), pp.375-381
- Publisher
- United States
- DOI
- 10.3945/ajcn.115.108712
- PMID
- 26762369
- PMCID
- PMC4733253
- ISSN
- 1938-3207
- eISSN
- 1938-3207
- Grant note
- P30 DK46200 / NIDDK NIH HHS UM1 CA176726 / NCI NIH HHS P30 DK046200 / NIDDK NIH HHS CA50385 / NCI NIH HHS HHSN275201000020C / PHS HHS DK58845 / NIDDK NIH HHS K01 DK103720 / NIDDK NIH HHS 1K01DK103720-01 / NIDDK NIH HHS
- Language
- English
- Date published
- 02/2016
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983996057902771
Metrics
21 Record Views