Long‐Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome

Lowell B. Anthony; Matthew H. Kulke; Martyn E. Caplin; Emily Bergsland; Kjell Öberg; Marianne Pavel; Dieter Hörsch; Richard R.P. Warner; Thomas M. O'Dorisio; Joseph S. Dillon; Pablo Lapuerta; Kenneth Kassler‐Taub; Wenjun Jiang

doi:10.1634/theoncologist.2018-0236

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Long‐Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome

Journal article

Open access

Peer reviewed

Long‐Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome

Lowell B. Anthony, Matthew H. Kulke, Martyn E. Caplin, Emily Bergsland, Kjell Öberg, Marianne Pavel, Dieter Hörsch, Richard R.P. Warner, Thomas M. O'Dorisio, Joseph S. Dillon, …

The oncologist (Dayton, Ohio), Vol.24(8), pp.e662-e670

01/16/2019

DOI: 10.1634/theoncologist.2018-0236

PMCID: PMC6693702

PMID: 30651397

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Abstract

This article examines pooled adverse events data for patients with carcinoid syndrome who received telotristat ethyl in phase II and II clinical trials, with a focus on long‐term safety, morbidity, and mortality in this patient population.

Diarrhea

Endocrinology

Malignant carcinoid syndrome

Neuroendocrine tumors

Serotonin

Telotristat ethyl

Tryptophan hydroxylase

Details

Title: Subtitle: Long‐Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome
Creators: Lowell B. Anthony - Markey Cancer Center
Matthew H. Kulke - Boston Medical Center
Martyn E. Caplin - The Royal Free Hospital
Emily Bergsland - University of California, San Francisco
Kjell Öberg - Uppsala University
Marianne Pavel - Charité - Universitätsmedizin Berlin
Dieter Hörsch - Zentralklinik Bad Berka
Richard R.P. Warner - Icahn School of Medicine at Mount Sinai
Thomas M. O'Dorisio - University of Iowa
Joseph S. Dillon - University of Iowa
Pablo Lapuerta - Lexicon Pharmaceuticals
Kenneth Kassler‐Taub - Lexicon Pharmaceuticals
Wenjun Jiang - Lexicon Pharmaceuticals
Resource Type: Journal article
Publication Details: The oncologist (Dayton, Ohio), Vol.24(8), pp.e662-e670
Publisher: John Wiley & Sons, Inc
DOI: 10.1634/theoncologist.2018-0236
PMID: 30651397
PMCID: PMC6693702
ISSN: 1083-7159
eISSN: 1549-490X
Language: English
Date published: 01/16/2019
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984359573902771

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