Journal article
Longitudinal Change of Clinical and Biological Measures in Early Parkinson's Disease: Parkinson's Progression Markers Initiative Cohort
Movement disorders, Vol.33(5), pp.771-782
05/2018
DOI: 10.1002/mds.27361
PMCID: PMC6001458
PMID: 29572948
Abstract
Objective:
The objective of this study was to assess longitudinal change in clinical and dopamine transporter imaging outcomes in early, untreated PD.
Methods:
We describe 5‐year longitudinal change of the MDS‐UPDRS and other clinical measures using results from the Parkinson's Progression Markers Initiative, a longitudinal cohort study of early Parkinson's disease (PD) participants untreated at baseline. We also provide data on the longitudinal change in dopamine transporter 123‐I Ioflupane striatal binding and correlation between the 2 measures.
Results:
A total of 423 PD participants were recruited, and 358 remain in the study at year 5. Baseline MDS‐UPDRS total score was 32.4 (standard deviation 13.1), and the average annual change (assessed medications OFF for the treated participants) was 7.45 (11.6), 3.11 (11.7), 4(11.9), 4.7 (11.1), and 1.74(11.9) for years 1, 2, 3, 4, and 5, respectively (
P
< .0001 for the change over time), with a steeper change in year 1. Dopaminergic therapy had a significant effect on the change of MDS‐UPDRS. There was a significant longitudinal change in dopamine transporter binding in all striatal regions (
P
< .001). There was a significant but weak correlation between MDS‐UPDRS and dopamine transporter binding at baseline and years 1, 2, and 4, but no correlation between the rate of change of the 2 variables.
Conclusions:
We present 5‐year longitudinal data on the change of the MDS‐UPDRS and other clinical and dopamine transporter imaging outcome measures in early PD. These data can be used for sample size estimates for interventional studies in the de novo PD population. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Details
- Title: Subtitle
- Longitudinal Change of Clinical and Biological Measures in Early Parkinson's Disease: Parkinson's Progression Markers Initiative Cohort
- Creators
- Tanya Simuni - Northwestern UniversityAndrew Siderowf - University of PennsylvaniaShirley Lasch - Institute for Neurodegenerative DisordersChris S Coffey - University of IowaChelsea Caspell‐Garcia - University of IowaDanna Jennings - Eli LillyCaroline M Tanner - University of CaliforniaJohn Q Trojanowski - University of PennsylvaniaLeslie M Shaw - University of PennsylvaniaJohn Seibyl - Institute for Neurodegenerative DisordersNorbert Schuff - University of CaliforniaAndrew Singleton - National Institutes of HealthKarl Kieburtz - University of RochesterArthur W Toga - University of Southern CaliforniaBrit Mollenhauer - Paracelsus‐Elena KlinikDoug Galasko - University of CaliforniaLana M Chahine - University of PennsylvaniaDaniel Weintraub - University of PennsylvaniaTatiana Foroud - Indiana UniversityDuygu Tosun - University of CaliforniaKathleen Poston - Stanford University Medical CenterVanessa Arnedo - Michael J Fox FoundationMark Frasier - Michael J Fox FoundationTodd Sherer - Michael J Fox FoundationSohini Chowdhury - Michael J Fox FoundationKenneth Marek - Institute for Neurodegenerative DisordersParkinson's Progression Marker Ini
- Resource Type
- Journal article
- Publication Details
- Movement disorders, Vol.33(5), pp.771-782
- DOI
- 10.1002/mds.27361
- PMID
- 29572948
- PMCID
- PMC6001458
- NLM abbreviation
- Mov Disord
- ISSN
- 0885-3185
- eISSN
- 1531-8257
- Publisher
- John Wiley and Sons Inc; Hoboken
- Grant note
- Pfizer Avid Radiopharmaceuticals The Michael J. Fox Foundation for Parkinson's Research Bristol‐Myers Squibb Genentech Biogen Idec F. Hoffmann‐La Roche AbbVie UCB Piramal GE Healthcare GlaxoSmithKline MesoScale Covance Lundbeck Merck
- Alternative title
- Early PD and MDS‐UPDRS and Dat Binding Change
- Language
- English
- Date published
- 05/2018
- Academic Unit
- Biostatistics
- Record Identifier
- 9983997306402771
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