Journal article
Longitudinal Effects of Sex, Aging, and Multiple Sclerosis Diagnosis on Function
Nursing research (New York), Vol.72(4), pp.281-291
07/01/2023
DOI: 10.1097/NNR.0000000000000656
PMCID: PMC10655905
PMID: 37350697
Abstract
BackgroundA gap in research about the trajectories of function among men and women aging with functional limitations because of multiple sclerosis (MS) hinders ability to plan for future needs.ObjectivesUsing a biopsychosocial model, we characterize how men and women with MS report changes over time in their function and test how person-level differences in age, diagnosis duration, and sex influence perceived function.MethodsA longitudinal study with multiple waves of surveys was used to collect data on participant perceptions of function, as well as demographic and contextual variables. Self-reported functional limitation was measured over a decade. The study participants were community residing with physician-diagnosed MS.ResultsThe people with MS had a diagnosis duration of about 13 years and were around 51 years of age, on average, at the start of the study. They were primarily women and non-Hispanic White. We analyzed the data using mixed-effects models. Subject-specific, functional limitation trajectories were described best with a quadratic growth model. Relative to men, women reported lower functional limitation and greater between-person variation and rates of acceleration in functional limitation scores.DiscussionResults suggest function progressed through two pathways for over a decade, particularly closer to diagnoses. Variability in trajectories between individuals based on sex and years since diagnosis of disease indicates that men and women with MS may experience perceptions of their function with age differently. This has implications for clinician advice to men and women with MS.
Details
- Title: Subtitle
- Longitudinal Effects of Sex, Aging, and Multiple Sclerosis Diagnosis on Function
- Creators
- Tracie C. Harrison - University of California, DavisShelley A. Blozis - University of California, DavisAlexa K. Stuifbergen - The University of Texas at AustinHeather Becker - The University of Texas at Austin
- Resource Type
- Journal article
- Publication Details
- Nursing research (New York), Vol.72(4), pp.281-291
- DOI
- 10.1097/NNR.0000000000000656
- PMID
- 37350697
- PMCID
- PMC10655905
- NLM abbreviation
- Nurs Res
- ISSN
- 0029-6562
- eISSN
- 1538-9847
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 11
- Language
- English
- Date published
- 07/01/2023
- Academic Unit
- Nursing
- Record Identifier
- 9984696722502771
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