Journal article
Longitudinal Evaluation of Cognitive Functioning in Young Children with Type 1 Diabetes over 18 Months
Journal of the International Neuropsychological Society, Vol.22(3), pp.293-302
03/2016
DOI: 10.1017/S1355617715001289
PMCID: PMC4856439
PMID: 26786245
Abstract
Objectives: Decrements in cognitive function may already be evident in young children with type 1 diabetes (T1D). Here we report prospectively acquired cognitive results over 18 months in a large cohort of young children with and without T1D. Methods: A total of 144 children with T1D (mean HbA1c: 7.9%) and 70 age-matched healthy controls (mean age both groups 8.5 years; median diabetes duration 3.9 years; mean age of onset 4.1 years) underwent neuropsychological testing at baseline and after 18-months of follow-up. We hypothesized that group differences observed at baseline would be more pronounced after 18 months, particularly in those T1D patients with greatest exposure to glycemic extremes. Results: Cognitive domain scores did not differ between groups at the 18 month testing session and did not change differently between groups over the follow-up period. However, within the T1D group, a history of diabetic ketoacidosis (DKA) was correlated with lower Verbal IQ and greater hyperglycemia exposure (HbA1c area under the curve) was inversely correlated to executive functions test performance. In addition, those with a history of both types of exposure performed most poorly on measures of executive function. Conclusions: The subtle cognitive differences between T1D children and nondiabetic controls observed at baseline were not observed 18 months later. Within the T1D group, as at baseline, relationships between cognition (Verbal IQ and executive functions) and glycemic variables (chronic hyperglycemia and DKA history) were evident. Continued longitudinal study of this T1D cohort and their carefully matched healthy comparison group is planned. (JINS, 2016, 21, 293–302)
Details
- Title: Subtitle
- Longitudinal Evaluation of Cognitive Functioning in Young Children with Type 1 Diabetes over 18 Months
- Creators
- M. Allison Cato - Division of Neurology, Nemours Children’s Health System, Jacksonville, FloridaNelly Mauras - Division of Endocrinology, Nemours Children’s Health System, Jacksonville, FloridaPaul Mazaika - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CaliforniaCraig Kollman - Jaeb Center for Health Research, Tampa, FloridaPeiyao Cheng - Jaeb Center for Health Research, Tampa, FloridaTandy Aye - Division of Pediatrics Endocrinology and Diabetes, Stanford University, Stanford, CaliforniaJodie Ambrosino - Yale Children’s Diabetes Program, Yale University, New Haven, ConnecticutRoy W Beck - Jaeb Center for Health Research, Tampa, FloridaKatrina J Ruedy - Jaeb Center for Health Research, Tampa, FloridaAllan L Reiss - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CaliforniaMichael Tansey - Division of Pediatric Psychology, University of Iowa Children’s Hospital, Iowa City, IowaNeil H White - 0 Departments of Pediatrics, Washington University, St. Louis, MissouriTamara Hershey - 1 Department of Psychiatry, Washington University, St. Louis, Missouri
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.22(3), pp.293-302
- DOI
- 10.1017/S1355617715001289
- PMID
- 26786245
- PMCID
- PMC4856439
- NLM abbreviation
- J Int Neuropsychol Soc
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Publisher
- Cambridge University Press; New York, USA
- Number of pages
- 10
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984070470002771
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