Longitudinal Partial Volume Correction in 2-[18F]-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography Studies of Alzheimer Disease

Charles B Malpas; Michael M Saling; Dennis Velakoulis; Patricia Desmond; Rodney J Hicks; Terence J O'Brien; Alzheimer Disease Neuroimaging Initiative

doi:10.1097/RCT.0000000000000256

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Longitudinal Partial Volume Correction in 2-[18F]-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography Studies of Alzheimer Disease

Journal article

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Longitudinal Partial Volume Correction in 2-[18F]-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography Studies of Alzheimer Disease

Charles B Malpas, Michael M Saling, Dennis Velakoulis, Patricia Desmond, Rodney J Hicks, Terence J O'Brien and Alzheimer Disease Neuroimaging Initiative

Journal of computer assisted tomography, Vol.39(4), pp.559-564

2015

DOI: 10.1097/RCT.0000000000000256

PMCID: PMC6318788

PMID: 26182225

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Abstract

Objective To investigate partial volume correction (PVC) of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography in Alzheimer disease in a longitudinal context. Methods A total of 115 participants were included, including 55 controls, 53 patients with mild cognitive impairment, and 7 patients with dementia of the Alzheimer type. Imaging was performed at baseline and 24 months. Partial volume corrected vs uncorrected rates of longitudinal change were compared for mesial temporal and cortical regions of interest. Results Partial volume correction increased apparent uptake, and this effect was greater at 24 months compared with baseline. Partial volume correction decreased the rate of decline, causing an apparent increase in uptake at 24 months compared with baseline. This effect was correlated with the structural atrophy. Conclusions These findings suggest that applying PVC in a longitudinal context in Alzheimer disease might produce unpredictable results. Accordingly, both PVC corrected and uncorrected data should be reported to ensure that the results are physiologically plausible.

2-[18F]-fluoro-2-Deoxy-d-glucose

partial volume effect

partial volume correction

Alzheimer disease

Details

Title: Subtitle: Longitudinal Partial Volume Correction in 2-[18F]-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography Studies of Alzheimer Disease
Creators: Charles B Malpas - Melbourne Brain Centre, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Michael M Saling - Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia
Dennis Velakoulis - Melbourne Brain Centre, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Patricia Desmond - Melbourne Brain Centre, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Rodney J Hicks - Departments of Radiology, University of Melbourne, Melbourne, Victoria, Australia
Terence J O'Brien - Melbourne Brain Centre, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Alzheimer Disease Neuroimaging Initiative
Contributors: Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: Journal of computer assisted tomography, Vol.39(4), pp.559-564
DOI: 10.1097/RCT.0000000000000256
PMID: 26182225
PMCID: PMC6318788
NLM abbreviation: J Comput Assist Tomogr
ISSN: 0363-8715
eISSN: 1532-3145
Language: English
Date published: 2015
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984051522302771

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