Longitudinal Relationship Between Tibiofemoral Contact Stress at Baseline and Worsening of Knee Pain Over 84 Months in the Multicenter Osteoarthritis Study

Kaitlin G Rabe; Tyler J Stockman; Andrew M Kern; Wolfgang Wirth; Felix Eckstein; Leena Sharma; John A Lynch; Michael C Nevitt; Donald D Anderson; Neil A Segal

doi:10.1097/PHM.0000000000001899

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Longitudinal Relationship Between Tibiofemoral Contact Stress at Baseline and Worsening of Knee Pain Over 84 Months in the Multicenter Osteoarthritis Study

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Longitudinal Relationship Between Tibiofemoral Contact Stress at Baseline and Worsening of Knee Pain Over 84 Months in the Multicenter Osteoarthritis Study

Kaitlin G Rabe, Tyler J Stockman, Andrew M Kern, Wolfgang Wirth, Felix Eckstein, Leena Sharma, John A Lynch, Michael C Nevitt, Donald D Anderson and Neil A Segal

American journal of physical medicine & rehabilitation, Vol.101(8), pp.726-732

08/01/2022

DOI: 10.1097/PHM.0000000000001899

PMCID: PMC8986881

PMID: 34620738

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https://www.ncbi.nlm.nih.gov/pmc/articles/8986881View

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Abstract

OBJECTIVEThe aim of the study was to determine whether tibiofemoral contact stress predicts risk for worsening knee pain over 84 ms in adults aged 50-79 yrs with or at elevated risk for knee osteoarthritis. DESIGNBaseline tibiofemoral contact stress was estimated using discrete element analysis. Other baseline measures included weight, height, hip-knee-ankle alignment, Kellgren-Lawrence grade, and Western Ontario and McMaster Universities Osteoarthritis Index pain subscale. Logistic regression models assessed the association between baseline contact stress and 84-mo worsening of Western Ontario and McMaster Universities Osteoarthritis Index pain subscale. RESULTSData from the dominant knee (72.6% Kellgren-Lawrence grade 0/1 and 27.4% Kellgren-Lawrence grade ≥ 2) of 208 participants (64.4% female, mean ± SD body mass index = 29.6 ± 5.1 kg/m 2 ) were analyzed. Baseline mean and peak contact stress were 3.3 ± 0.9 and 9.4 ± 4.3 MPa, respectively. Forty-seven knees met the criterion for worsening pain. The highest tertiles in comparison with the lowest tertiles of mean (odds ratio [95% confidence interval] = 2.47 [1.03-5.95], P = 0.04) and peak (2.49 [1.03-5.98], P = 0.04) contact stress were associated with worsening pain at 84 mos, after adjustment for age, sex, race, clinic site, and baseline pain. Post hoc sensitivity analyses including adjustment for body mass index and hip-knee-ankle alignment attenuated the effect. CONCLUSIONSThese findings suggest that elevated tibiofemoral contact stress can predict the development of worsening of knee pain.

Details

Title: Subtitle: Longitudinal Relationship Between Tibiofemoral Contact Stress at Baseline and Worsening of Knee Pain Over 84 Months in the Multicenter Osteoarthritis Study
Creators: Kaitlin G Rabe - University of California, San Francisco
Tyler J Stockman
Andrew M Kern
Wolfgang Wirth
Felix Eckstein
Leena Sharma
John A Lynch
Michael C Nevitt
Donald D Anderson
Neil A Segal
Resource Type: Journal article
Publication Details: American journal of physical medicine & rehabilitation, Vol.101(8), pp.726-732
DOI: 10.1097/PHM.0000000000001899
PMID: 34620738
PMCID: PMC8986881
NLM abbreviation: Am J Phys Med Rehabil
ISSN: 0894-9115
eISSN: 1537-7385
Language: English
Date published: 08/01/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Epidemiology; Orthopedics and Rehabilitation; Industrial and Systems Engineering
Record Identifier: 9984304699602771

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