Journal article
Longitudinal Study of Cervical Squamous Intraepithelial Lesions in Human Immunodeficiency Virus (HIV)-Seropositive and At-Risk HIV-Seronegative Women
The Journal of infectious diseases, Vol.188(1), pp.128-136
07/01/2003
DOI: 10.1086/375783
PMID: 12825181
Abstract
We examined incidence and correlates of progression and regression of abnormal cervical cytologic test results, defined as at least low-grade squamous intraepithelial lesions (SILs), in 774 human immunodeficiency virus (HIV)-seropositive and 391 HIV-seronegative women monitored semiannually for up to 5.5 years. During follow-up, 224 (35%) HIV-seropositive women and 34 (9%) HIV-seronegative women had incident SILs detected by Pap test; 47 (7%) HIV-seropositive women developed high-grade lesions. The incidence of SILs was 11.5 cases among HIV-seropositive and 2.6 cases among HIV-seronegative women per 100 person-years of observation (rate ratio, 4.5; 95% confidence interval, 3.1–6.4; P<.001). Risk of incident SILs and likelihood of Pap test progression were increased among HIV-seropositive women with CD4+ lymphocyte counts <500 cells/mm3 and among women with human papillomavirus (HPV) infection, with risk-ordering from low-to high-risk HPV type. SIL regression was less likely among HIV-seropositive women with higher HIV loads. No beneficial effect of highly active antiretroviral therapy was demonstrated.
Details
- Title: Subtitle
- Longitudinal Study of Cervical Squamous Intraepithelial Lesions in Human Immunodeficiency Virus (HIV)-Seropositive and At-Risk HIV-Seronegative Women
- Creators
- Paula Schuman - Wayne State UniversitySuzanne E. Ohmit - Wayne State UniversityRobert S. Klein - Albert Einstein College of MedicineAnn Duerr - Centers for Disease Control and PreventionSusan Cu-Uvin - Miriam HospitalDenise J. Jamieson - Centers for Disease Control and PreventionJean Anderson - Johns Hopkins UniversityKeerti V. Shah - Johns Hopkins MedicineHIV Epidemiology Research Study (HERS) Group
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.188(1), pp.128-136
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/375783
- PMID
- 12825181
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 07/01/2003
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446537002771
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