Journal article
Longitudinal analysis of bacterial vaginosis: findings from the hiv epidemiology research study
Obstetrics and gynecology (New York. 1953), Vol.98(4), pp.656-663
10/2001
DOI: 10.1016/S0029-7844(01)01525-3
PMID: 11576584
Abstract
OBJECTIVE:
To determine the natural history of bacterial vaginosis in women with or at risk for human immunodeficiency virus (HIV).
METHODS:
A cohort of 854 HIV-infected women and 434 HIV-uninfected women from four US sites was followed prospectively with gynecologic exams every 6 months over a 5-year period. The prevalence, incidence, persistence, and severity of bacterial vaginosis, which was defined using a Gram-staining scoring system, were calculated using generalized estimating equation methods.
RESULTS:
In adjusted analyses, HIV-infected women had a higher prevalence of bacterial vaginosis than HIV-uninfected women (adjusted odds ratio [OR] 1.29; 95% confidence interval [CI] 1.08, 1.55). Although HIV-infected women were not more likely to have incident infections, they were more likely to have persistence of their infections (adjusted OR 1.49; 95% CI 1.18, 1.89). Similarly, immunocompromised women (CD4+ cell count less than 200 cells/μL) were more likely than HIV-infected women with higher CD4+ cell counts (more than 500 cells/μL) to have prevalent (adjusted OR 1.29; 95% CI 1.03, 1.60) and persistent (adjusted OR 1.38; 95% CI 1.01, 1.91) bacterial vaginosis infections, but not more likely to have incident infections. Immunocompromised women had more severe bacterial vaginosis by both clinical criteria (adjusted OR 1.40; 95% CI 1.08, 1.82) and by Gram-staining criteria (adjusted OR 1.50; 95% CI 1.12, 2.00).
CONCLUSIONS:
Bacterial vaginosis is more prevalent and persistent among HIV-infected women, particularly among those who are immunocompromised. Immunocompromised women are more likely than HIV-infected women with higher CD4+ cell counts to have severe bacterial vaginosis.
Details
- Title: Subtitle
- Longitudinal analysis of bacterial vaginosis: findings from the hiv epidemiology research study
- Creators
- Denise J Jamieson - Centers for Disease Control and PreventionAnn DuerrRobert S Klein - Albert Einstein College of MedicinePangaja Paramsothy - Wayne State UniversityWilliam Brown - Miriam HospitalSusan Cu-Uvin - Johns Hopkins UniversityAnne Rompalo - Wayne State UniversityJack Sobel - Miriam HospitalHIV Epidemiology Research Study (HERS) Group
- Resource Type
- Journal article
- Publication Details
- Obstetrics and gynecology (New York. 1953), Vol.98(4), pp.656-663
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0029-7844(01)01525-3
- PMID
- 11576584
- ISSN
- 0029-7844
- eISSN
- 1873-233X
- Language
- English
- Date published
- 10/2001
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446536302771
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