Journal article
Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia
Diabetes (New York, N.Y.), Vol.64(5), pp.1770-1779
05/2015
DOI: 10.2337/db14-1445
PMCID: PMC4407847
PMID: 25488901
Abstract
Significant regional differences in gray and white matter volume and subtle cognitive differences between young diabetic and nondiabetic children have been observed. Here, we assessed whether these differences change over time and the relation with dysglycemia. Children ages 4 to <10 years with (n = 144) and without (n = 72) type 1 diabetes (T1D) had high-resolution structural MRI and comprehensive neurocognitive tests at baseline and 18 months and continuous glucose monitoring and HbA1c performed quarterly for 18 months. There were no differences in cognitive and executive function scores between groups at 18 months. However, children with diabetes had slower total gray and white matter growth than control subjects. Gray matter regions (left precuneus, right temporal, frontal, and parietal lobes and right medial-frontal cortex) showed lesser growth in diabetes, as did white matter areas (splenium of the corpus callosum, bilateral superior-parietal lobe, bilateral anterior forceps, and inferior-frontal fasciculus). These changes were associated with higher cumulative hyperglycemia and glucose variability but not with hypoglycemia. Young children with T1D have significant differences in total and regional gray and white matter growth in brain regions involved in complex sensorimotor processing and cognition compared with age-matched control subjects over 18 months, suggesting that chronic hyperglycemia may be detrimental to the developing brain.
Details
- Title: Subtitle
- Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia
- Creators
- Nelly Mauras - Division of Endocrinology, Diabetes & Metabolism, Nemours Children's Clinic, Jacksonville, FL nmauras@nemours.orgPaul Mazaika - Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CABruce Buckingham - Department of Pediatrics, Stanford University School of Medicine, Stanford, CAStuart Weinzimer - Department of Pediatrics, Yale University School of Medicine, New Haven, CTNeil H White - Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MOEva Tsalikian - Pediatric Endocrinology, University of Iowa, Iowa City, IATamara Hershey - Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO Department of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MOAllison Cato - Division of Neurology, Nemours Children's Clinic, Jacksonville, FLPeiyao Cheng - Jaeb Center for Health Research, Tampa, FLCraig Kollman - Jaeb Center for Health Research, Tampa, FLRoy W Beck - Jaeb Center for Health Research, Tampa, FLKatrina Ruedy - Jaeb Center for Health Research, Tampa, FLTandy Aye - Department of Pediatrics, Stanford University School of Medicine, Stanford, CALarry Fox - Division of Endocrinology, Diabetes & Metabolism, Nemours Children's Clinic, Jacksonville, FLAna Maria Arbelaez - Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MODarrell Wilson - Department of Pediatrics, Stanford University School of Medicine, Stanford, CAMichael Tansey - Pediatric Endocrinology, University of Iowa, Iowa City, IAWilliam Tamborlane - Department of Pediatrics, Yale University School of Medicine, New Haven, CTDaniel Peng - Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CAMatthew Marzelli - Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA Department of Bioengineering, Stanford University School of Medicine, Stanford, CAKaren K Winer - Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MDAllan L Reiss - Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA Department of Pediatrics, Stanford University School of Medicine, Stanford, CA Department of Radiology, Stanford University School of Medicine, Stanford, CADiabetes Research in Children Network (DirecNet)
- Resource Type
- Journal article
- Publication Details
- Diabetes (New York, N.Y.), Vol.64(5), pp.1770-1779
- DOI
- 10.2337/db14-1445
- PMID
- 25488901
- PMCID
- PMC4407847
- ISSN
- 0012-1797
- eISSN
- 1939-327X
- Grant note
- UL1 TR000142 / NCATS NIH HHS HD-41908 / NICHD NIH HHS HD-41915, / NICHD NIH HHS R01 HD078463 / NICHD NIH HHS U10 HD041906 / NICHD NIH HHS UL1 TR000448 / NCATS NIH HHS HD-56526 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS HD-41906 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS HD-41918 / NICHD NIH HHS U10 HD041908 / NICHD NIH HHS 1R01-HD-078463 / NICHD NIH HHS UL1 RR024992 / NCRR NIH HHS U10 HD056526 / NICHD NIH HHS P30 DK045735 / NIDDK NIH HHS UL1-RR-024992 / NCRR NIH HHS U01-HD-41890 / NICHD NIH HHS U01 HD041890 / NICHD NIH HHS
- Language
- English
- Date published
- 05/2015
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093342002771
Metrics
9 Record Views