Journal article
Longitudinal assessment of occupational determinants of chlorpyrifos exposure in adolescent pesticide workers in Egypt
International journal of hygiene and environmental health, Vol.220(8), pp.1356-1362
11/2017
DOI: 10.1016/j.ijheh.2017.09.006
PMCID: PMC5671904
PMID: 28939184
Abstract
Chlorpyrifos (CPF) is an organophosphourus insecticide applied to cotton fields by adolescents employed by the Egyptian Ministry of Agriculture. Urinary 3,5,6-trichloro-2-pyridinol (TCPy) is a biomarker of CPF exposure that has substantial variability among these applicators. In order to identify predictors of CPF exposure, we conducted a longitudinal study of 43 adolescent pesticide applicators in Egypt from April 2010 to January 2011 in Egypt. Urinary TCPy was quantified at 25 time-points, prior to, during, and following application. We used log-linear regression and a best subset selection approach to identify the exposure determinants that were most predictive of cumulative TCPy and participants’ highest TCPy values (peak exposure). Applicators had cumulative urinary TCPy levels ranging from 167 to 49,8208μg/g creatinine. Total hours applying CPF (semi-partial r2=0.32), and total hours in the field applying other pesticides (semi-partial r2=0.08) were the strongest predictors of cumulative TCPy. Applicators had peak urinary TCPy levels ranging from 4 to 5715μg/g creatinine. The amount of time applying pesticides prior to blood draw was the strongest predictor of peak TCPy (semi-partial r2=0.30). We also observed evidence that wearing clean clothes to work was associated with lower longitudinal TCPy. Our results suggest there is an opportunity for targeted interventions, particularly related to hygiene or implementation of personal protective equipment usage to reduce CPF exposure among adolescent pesticide workers.
Details
- Title: Subtitle
- Longitudinal assessment of occupational determinants of chlorpyrifos exposure in adolescent pesticide workers in Egypt
- Creators
- Catherine L Callahan - Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United StatesLamya A Hamad - Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United StatesJames R Olson - Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United StatesAhmed A Ismail - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United StatesGaafar Abdel-Rasoul - Community Medicine and Public Health Department, Faculty of Medicine, Menoufia University, Shebin El-Kom 32511, EgyptOlfat Hendy - Clinical Pathology and Hematology and Immunology, Menoufia University, Shebin El-Kom, EgyptDiane S Rohlman - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United StatesMatthew R Bonner - Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United States
- Resource Type
- Journal article
- Publication Details
- International journal of hygiene and environmental health, Vol.220(8), pp.1356-1362
- DOI
- 10.1016/j.ijheh.2017.09.006
- PMID
- 28939184
- PMCID
- PMC5671904
- NLM abbreviation
- Int J Hyg Environ Health
- ISSN
- 1438-4639
- eISSN
- 1618-131X
- Publisher
- Elsevier GmbH
- Grant note
- DOI: 10.13039/100000061, name: Fogarty International Center; DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: R211ES017223, R01ES022163; DOI: 10.13039/100000054, name: National Cancer Institute, award: R25CA113951
- Language
- English
- Date published
- 11/2017
- Academic Unit
- Occupational and Environmental Health; International Programs; Injury Prevention Research Center
- Record Identifier
- 9984214827102771
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