Journal article
Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance
The American journal of psychiatry, Vol.159(7), pp.1183-1189
07/2002
DOI: 10.1176/appi.ajp.159.7.1183
PMID: 12091197
Abstract
Studies suggest the presence of premorbid cognitive impairment in patients with schizophrenia, yet the onset and course of these deficits remain unclear. The purpose of this study was to investigate the longitudinal course of premorbid cognitive functioning in individuals with schizophrenia by using prospective data obtained from scholastic test results.
Scores from grades 4, 8, and 11 on the Iowa Tests of Basic Skills and the Iowa Tests of Educational Development were obtained for 70 subjects who later developed schizophrenia. The mean percentile rank of the subjects' scores in the areas of vocabulary, reading comprehension, language, mathematics, sources of information, and an overall composite category were compared with state norms.
The subjects scored below the 50th percentile for each category in all three grades, but only language, reading, sources of information, and composite scores from grade 11 were significantly below state norms. With regard to longitudinal course, there was a significant linear decrease in language scores over time. Scores from grade 11 were positively correlated with WAIS-R IQ, verbal fluency, and Rey Auditory Verbal Learning scores at first illness episode. Scores from grade 11 were not significantly correlated with age at illness onset or ratings of disorganized, psychotic, or negative symptoms.
Scholastic test scores at grades 4 and 8 were nonsignificantly below average in this group of children who later developed schizophrenia. However, test scores dropped significantly between grades 8 and 11. This corresponds to ages 13-16 years, or the onset of puberty. Poor or declining scholastic performance may be a precursor to the cognitive impairment seen during the first episode of illness.
Details
- Title: Subtitle
- Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance
- Creators
- Rebecca Fuller - Department of Psychiatry, Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA. bfuller@mrpc.umaryland.eduPeg NopoulosStephan ArndtDan O'LearyBeng-Choon HoNancy C Andreasen
- Resource Type
- Journal article
- Publication Details
- The American journal of psychiatry, Vol.159(7), pp.1183-1189
- DOI
- 10.1176/appi.ajp.159.7.1183
- PMID
- 12091197
- NLM abbreviation
- Am J Psychiatry
- ISSN
- 0002-953X
- eISSN
- 1535-7228
- Publisher
- United States
- Grant note
- MH 43271 / NIMH NIH HHS MH 40856 / NIMH NIH HHS MH 31593 / NIMH NIH HHS MH 00625 / NIMH NIH HHS
- Language
- English
- Date published
- 07/2002
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984003994502771
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