Journal article
Longitudinal changes in symptom-based female and male LUTS clusters
Neurourology and urodynamics, Vol.39(1), pp.393-402
01/01/2020
DOI: 10.1002/nau.24219
PMCID: PMC7381999
PMID: 31765491
Abstract
Aims Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments received. Methods Patient-reported LUTS and treatment data were collected at multiple time points between baseline and 12 months from the LURN Observational Cohort study. LUTS severity scores were calculated to summarize changes in symptom reporting over time in previously identified LURN clusters. Repeated measures linear regression models tested adjusted associations between cluster membership and severity scores. Results Four-hundred seventeen men and 396 women were classified into improved, unchanged, and worsened symptoms between baseline and 12 months (men: 44.1%, 40.5%, and 15.3%; women: 55.8%, 33.1%, 11.1%, respectively). Improvement in LUTS severity scores varied by cluster (estimated adjusted mean change from baseline range: -.04 change in standard deviations of severity scores (Delta SD) to -.67 Delta SD). Prostate surgery was associated with improved severity scores (-.63 Delta SD) in men, while stress incontinence surgery was associated with improved severity scores (-.88 Delta SD) in women. Conclusion Symptom improvement varied by cluster indicating response to therapy differs amongst subtypes of patients with LUTS. The differential improvement of patients in clusters suggests mechanistic differences between clusters and may aid in selecting more targeted treatments in the future.
Details
- Title: Subtitle
- Longitudinal changes in symptom-based female and male LUTS clusters
- Creators
- Cindy L. Amundsen - Duke UniversityAbigail R. Smith - Arbor Research Collaborative for HealthJohn O. L. DeLancey - University of Michigan–Ann ArborCatherine S. Bradley - University of IowaKathryn E. Flynn - Medical College of WisconsinKimberly S. Kenton - Northwestern UniversityH. Henry Lai - Washington University in St. LouisDavid Cella - Northwestern UniversityJames W. Griffith - Northwestern UniversityVictor P. Andreev - Arbor Research Collaborative for HealthJ. Eric Jelovsek - Duke UniversityAlice B. Liu - University of WashingtonZiya Kirkali - National Institute of Diabetes and Digestive and Kidney DiseasesClaire C. Yang - University of WashingtonKevin Weinfurt - Duke Univ, Durham, NC 27707 USAKathryn Flynn - Medical College of WisconsinMatthew O. Fraser - Duke Univ, Durham, NC 27707 USATodd Harshbarger - Duke Univ, Durham, NC 27707 USAEric Jelovsek - Duke Univ, Durham, NC 27707 USAAaron Lentz - Duke Univ, Durham, NC 27707 USADrew Peterson - Duke Univ, Durham, NC 27707 USANazema Siddiqui - Duke Univ, Durham, NC 27707 USAAlison Weidner - Duke Univ, Durham, NC 27707 USACarrie Dombeck - Duke Univ, Durham, NC 27707 USARobin Gilliam - Duke Univ, Durham, NC 27707 USAAkira Hayes - Duke Univ, Durham, NC 27707 USAShantae McLean - Duke Univ, Durham, NC 27707 USAKarl Kreder - University of IowaBradley A. Erickson - University of IowaSusan K. Lutgendorf - University of IowaVince Magnotta - Univ Iowa, Iowa City, IA USAMichael A. O'Donnell - University of IowaVivian Sung - Univ Iowa, Iowa City, IA USAAhmad Alzubaidi - University of IowaBrian Helfand - Northwestern Univ, Chicago, IL 60611 USAChristina Lewicky-Gaupp - Northwestern UniversityTodd Parrish - Northwestern UniversityJennie Yufen Chen - Northwestern UniversityMargaret Mueller - Northwestern UniversitySarah Buono - Northwestern UniversityMaria Corona - Northwestern UniversityBeatriz Menendez - Northwestern UniversityAlexis Siurek - Northwestern UniversityMeera Tavathia - Northwestern UniversityVeronica Venezuela - Northwestern UniversityAzra Muftic - Northwestern UniversityPooja Talaty - Northwestern UniversityJasmine Nero - Northwestern UniversityJ. Quentin Clemens - Univ Michigan Hlth Syst, Ann Arbor, MI USAMitch Berger - Univ Michigan Hlth Syst, Ann Arbor, MI USAJohn DeLancey - Univ Michigan Hlth Syst, Ann Arbor, MI USADee Fenner - Univ Michigan Hlth Syst, Ann Arbor, MI USARick Harris - Univ Michigan Hlth Syst, Ann Arbor, MI USASteve Harte - Univ Michigan Hlth Syst, Ann Arbor, MI USAAnne P. Cameron - Univ Michigan Hlth Syst, Ann Arbor, MI USAJohn Wei - Univ Michigan Hlth Syst, Ann Arbor, MI USAMorgen Barroso - Univ Michigan Hlth Syst, Ann Arbor, MI USALinda Drnek - Univ Michigan Hlth Syst, Ann Arbor, MI USAGreg Mowatt - Univ Michigan Hlth Syst, Ann Arbor, MI USAJulie Tumbarello - Univ Michigan Hlth Syst, Ann Arbor, MI USAJohn L. Gore - Univ Washington, Seattle, WA 98195 USAAlice Liu - University of WashingtonBrenda Vicars - Univ Washington, Seattle, WA 98195 USAGerald L. Andriole - Washington Univ, St Louis, MO 63110 USAJoshua Shimony - Washington Univ, St Louis, MO 63110 USASusan Mueller - Washington Univ, St Louis, MO 63110 USAHeather Wilson - Washington Univ, St Louis, MO 63110 USADeborah Ksiazek - Washington Univ, St Louis, MO 63110 USAAleksandra Klim - Washington Univ, St Louis, MO 63110 USAChristopher Mullins - NIDDK, Div Kidney Urol & Hematol, Bethesda, MD 20892 USATamara Bavendam - NIDDK, Div Kidney Urol & Hematol, Bethesda, MD 20892 USARobert Star - NIDDK, Div Kidney Urol & Hematol, Bethesda, MD 20892 USAJenna Norton - NIDDK, Div Kidney Urol & Hematol, Bethesda, MD 20892 USARobert Merion - Arbor Res Collaborat Hlth, Ann Arbor, MI USABrenda Gillespie - Arbor Res Collaborat Hlth, Ann Arbor, MI USAGang Liu - Arbor Res Collaborat Hlth, Ann Arbor, MI USAMelissa Fava - Arbor Res Collaborat Hlth, Ann Arbor, MI USAPeg Hill-Callahan - Arbor Res Collaborat Hlth, Ann Arbor, MI USATimothy Buck - Arbor Res Collaborat Hlth, Ann Arbor, MI USAMargaret Helmuth - Arbor Research Collaborative for HealthJon Wiseman - Arbor Res Collaborat Hlth, Ann Arbor, MI USAJulieanne Lock - Arbor Res Collaborat Hlth, Ann Arbor, MI USALower Urinary Tract Dysfunction Research Network (LURN) Study Group
- Resource Type
- Journal article
- Publication Details
- Neurourology and urodynamics, Vol.39(1), pp.393-402
- DOI
- 10.1002/nau.24219
- PMID
- 31765491
- PMCID
- PMC7381999
- NLM abbreviation
- Neurourol Urodyn
- ISSN
- 0733-2467
- eISSN
- 1520-6777
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- National Institutes of Health's National Center for Advancing Translational Sciences DK097772; DK097776; DK097779; DK097780; DK099879; DK099932; DK100011; DK100017 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 01/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Epidemiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984315564102771
Metrics
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