Journal article
Longitudinal changes of health-related quality of life in childhood chronic kidney disease
Pediatric nephrology (Berlin, West), Vol.38(12), pp.4127-4136
12/2023
DOI: 10.1007/s00467-023-06069-8
PMCID: PMC10591962
PMID: 37428223
Abstract
Background
Few longitudinal studies have evaluated the impact of chronic kidney disease (CKD) duration on health-related quality of life (HRQOL). The study’s aim was to determine how HRQOL changes over time in childhood CKD.
Methods
Study participants were children in the chronic kidney disease in children (CKiD) cohort who completed the pediatric quality of life inventory (PedsQL) on three or more occasions over the course of two or more years. Generalized gamma (GG) mixed-effects models were applied to assess the effect of CKD duration on HRQOL while controlling for selected covariates.
Results
A total of 692 children (median age = 11.2) with a median of 8.3 years duration of CKD were evaluated. All subjects had a GFR greater than 15 ml/min/1.73 m2. GG models with child self-report PedsQL data indicated that longer CKD duration was associated with improved total HRQOL and the 4 domains of HRQOL. GG models with parent-proxy PedsQL data indicated that longer duration was associated with better emotional but worse school HRQOL. Increasing trajectories of child self-report HRQOL were observed in the majority of subjects, while parents less frequently reported increasing trajectories of HRQOL. There was no significant relationship between total HRQOL and time-varying GFR.
Conclusions
Longer duration of the disease is associated with improved HRQOL on child self-report scales; however, parent-proxy results were less likely to demonstrate any significant change over time. This divergence could be due to greater optimism and accommodation of CKD in children. Clinicians can use these data to better understand the needs of pediatric CKD patients.
Details
- Title: Subtitle
- Longitudinal changes of health-related quality of life in childhood chronic kidney disease
- Creators
- Joann Carlson - Robert Wood Johnson University HospitalArlene C. Gerson - Johns Hopkins MedicineMatthew B. Matheson - Johns Hopkins UniversitySharon Manne - Robert Wood Johnson University HospitalMarc Lande - University of Rochester Medical CenterLyndsay Harshman - University of IowaRebecca J. Johnson - Children's Mercy HospitalShlomo Shinnar - Albert Einstein College of MedicineAmy J. Kogon - Children's Hospital of PhiladelphiaBradley Warady - Children's Mercy HospitalSusan Furth - Children's Hospital of PhiladelphiaStephen Hooper - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.38(12), pp.4127-4136
- DOI
- 10.1007/s00467-023-06069-8
- PMID
- 37428223
- PMCID
- PMC10591962
- NLM abbreviation
- Pediatr Nephrol
- ISSN
- 0931-041X
- eISSN
- 1432-198X
- Grant note
- DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: U01 DK066143, U01 DK066174, U24 DK082194, U24 DK066116; DOI: 10.13039/100009633, name: Eunice Kennedy Shriver National Institute of Child Health and Human Development, award: U01 DK066174; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: U01 DK066143, U01 DK066174
- Language
- English
- Electronic publication date
- 07/10/2023
- Date published
- 12/2023
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Radiation Oncology
- Record Identifier
- 9984444868302771
Metrics
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