Journal article
Longitudinal distribution of ozone absorption in the lung: Comparison of cigarette smokers and nonsmokers
Toxicology and applied pharmacology, Vol.236(3), pp.270-275
2009
DOI: 10.1016/j.taap.2009.02.006
PMID: 19233220
Abstract
In nonsmokers, ozone (O
3) is removed primarily by the epithelial lining fluid (ELF) of the conducting airways. We hypothesized that cigarette smokers, whose ELF antioxidant capacity may be limited by smoking, would remove less O
3 from their conducting airways than nonsmokers. We recruited 29 nonsmokers (17M, 12F) and 30 smokers (19M, 11F, 4
±
4 pack-years) with similar anthropometric characteristics and measured the longitudinal distribution of O
3 using the bolus inhalation method. We also assessed the physiological effect of this transient exposure regimen using forced spirometry and capnography. Contrary to our hypothesis, the penetration volume at which 50% of a bolus was absorbed was not different between smokers and nonsmokers (97.1
±
5.4 mL versus 97.9
±
5.8 mL,
p
=
0.92). However, smokers did experience an increase in the slope of the alveolar plateau of the capnogram (
S
N) (8.1
±
3.2%,
p
=
0.02) and a small decrease in FEV
1 (−
1.3
±
0.6%,
p
=
0.03), whereas nonsmokers did not (ΔFEV
1 −
0.1
±
0.5% and Δ
S
N −
0.2
±
2.5%,
p
>
0.10). Thus, smokers are more sensitive to inhaled O
3 boluses than nonsmokers, despite a similar internal dose distribution.
Details
- Title: Subtitle
- Longitudinal distribution of ozone absorption in the lung: Comparison of cigarette smokers and nonsmokers
- Creators
- Melissa L Bates - Interdisciplinary Graduate Degree Program in Physiology, Pennsylvania State University, University Park, PA 16802, USATimothy M Brenza - Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USAAbdellaziz Ben-Jebria - Interdisciplinary Graduate Degree Program in Physiology, Pennsylvania State University, University Park, PA 16802, USARebecca Bascom - Division of Pulmonary, Allergy and Critical Care Medicine, Penn State College of Medicine, Hershey, PA 17033, USAJames S Ultman - Interdisciplinary Graduate Degree Program in Physiology, Pennsylvania State University, University Park, PA 16802, USA
- Resource Type
- Journal article
- Publication Details
- Toxicology and applied pharmacology, Vol.236(3), pp.270-275
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.taap.2009.02.006
- PMID
- 19233220
- ISSN
- 0041-008X
- eISSN
- 1096-0333
- Language
- English
- Date published
- 2009
- Academic Unit
- Stead Family Department of Pediatrics; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984002370602771
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