Journal article
Longitudinal investigation of haematological alterations among permethrin-exposed pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture study
Occupational and environmental medicine (London, England), Vol.76(7), pp.467-470
07/2019
DOI: 10.1136/oemed-2018-105559
PMCID: PMC7359816
PMID: 30962255
Abstract
Permethrin use has been associated with an increased risk of multiple myeloma (MM) among pesticide applicators. However, the biological plausibility and mechanisms underlying this association are not fully understood. The aim of this study was to assess whether exposure to permethrin is related to haematological alterations among occupationally exposed pesticide applicators.
We conducted a longitudinal study among 33 pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture study comparing haematological parameters in the offseason with the day after permethrin exposure and, for 27 participants, approximately 3 weeks postexposure. Complete blood counts with white blood cell differential and lymphocyte subsets were measured at each visit. Multivariate linear mixed effects models were used to assess the relationship between natural log-transformed haematological parameters and exposure to permethrin.
The adjusted geometric mean immature granulocyte count was elevated among pesticide applicators following permethrin exposure compared with their offseason levels (37% increase, 95% CI 6% to 76%). Modest but statistically significant (p<0.05) alterations in red blood cell (RBC) parameters (eg, decreased RBC count and haemoglobin and increased mean corpuscular volume and RBC distribution width-SD) were also observed the day after permethrin use compared with offseason levels; decreases in RBC count and haemoglobin and increases in RBC distribution width-SD persisted approximately 3 weeks after permethrin use.
Altered haematological parameters could be indicative of disrupted haematopoiesis, providing insights into the biological plausibility of the observed association between permethrin use and MM risk among pesticide applicators.
Details
- Title: Subtitle
- Longitudinal investigation of haematological alterations among permethrin-exposed pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture study
- Creators
- Joseph J Shearer - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USALaura E Beane Freeman - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USADanping Liu - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USAGabriella Andreotti - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USAJennifer Hamilton - Department of Epidemiology, University of Iowa, Iowa City, Iowa, USAJulie Happel - Department of Pathology, University of Iowa Hospital and Clinics, Iowa City, Iowa, USACharles F Lynch - Department of Pathology, University of Iowa Hospital and Clinics, Iowa City, Iowa, USAMichael C Alavanja - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USAJonathan N Hofmann - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
- Resource Type
- Journal article
- Publication Details
- Occupational and environmental medicine (London, England), Vol.76(7), pp.467-470
- DOI
- 10.1136/oemed-2018-105559
- PMID
- 30962255
- PMCID
- PMC7359816
- NLM abbreviation
- Occup Environ Med
- ISSN
- 1351-0711
- eISSN
- 1470-7926
- Publisher
- England
- Grant note
- P30 CA086862 / NCI NIH HHS Z01 CP010119 / NCI NIH HHS
- Language
- English
- Date published
- 07/2019
- Academic Unit
- Epidemiology
- Record Identifier
- 9983996069502771
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